The Relevant Research About Serum Protein Factors And Clinical Symptoms Of Schizophrenia

Objective 1.To investigate the changes of the three kinds of serum protein factors, nerve growth factor-? (NGF-?), interleukin 1? (IL-1?), myelin basic protein (MBP) in with positive and negative symptoms of schizophrenia and the relationship between the serum concentration and PANSS score.2. To investigate the relationship between the serum concentration and cognitive function in patients with schizophrenia.Methods ?Our study used case-control. The serum concentration of three kinds of protein factors in 46 patients with positive symptoms of schizophrenia?37 patients with negative symptoms of schizophrenia and 60 healthy controls were assayed by ELISA respectively, using the PANSS scale score of patients with first-episode schizophrenia. ?The serum concentration of three kinds of protein factors in 46 patients with schizophrenia and 50 healthy controls were assayed by ELISA respectively, applying the system evaluation tool-MCCB to assess cognitive function in 46 patients with schizophrenia and 50 healthy controls and whether there is a relevance between three kinds of protein factors and cognitive function score.Results The first study:?Three group comparison of IL-1?, F=111.835, P< 0.05, the difference was statistically significant, further pairwise comparisons, control group was lower than the group of positive symptoms and negative symptoms group, and while positive symptoms group IL-1? concentration below concentration of patients with negative symptoms group;three group comparison of MBP, F=95.198, P<0.05, the difference was statistically significant, further pairwise comparisons, control group was lower than the group of positive symptoms and negative symptoms group, and while positive symptoms group IL-1? concentration below concentration of patients with negative symptoms group;?Three group comparison of NGF-?, F=146.529, P<0.05, the difference was statistically significant, further pairwise comparisons, control group was lower than the group of positive symptoms and negative symptoms group[(21.25�8.65 vs.44.93�9.77), (18.73�5.95 vs.44.93�9.77)] ng/ml(P<0.05), but while there were no significant differences in two groups of schizophrenia patients. ?There was a positive correlation between the serum concentration of IL-1?, MBP in with negative symptoms of schizophrenia patients and the negative symptoms score of PANSS. The second study:?The serum concentration of IL-1?, MBP in schizophrenia patients are significantly higher than the control group, while the level of NGF-? in schizophrenia patients are significantly lower than the control group (P<0.05) ?There was a negative correlation between the serum concentration of IL-1?in with schizophrenia patients and the WMS-III score in MCCB, while there was a negative correlation between the serum concentration of IL-1?in with schizophrenia patients and the BACS-BC score in MCCB.Conclusions the first study ?The serum concentration of IL-1?, MBP in schizophrenia patients are significantly higher than the control group, but the level of NGF-? in schizophrenia patients is lower than the control group. It shows pro-inflammatory state, nerve injury and nerve nutritional deficiencies have been in existence in the early stages of schizophrenia, so early treatment is necessary. ?Through the PANSS score, we divided the patients into a group of patients with predominantly positive symptoms and a group of patients with predominantly negative symptoms, and find:the serum concentration of IL-1?, MBP in with positive symptoms of schizophrenia patients are lower than with negative symptoms of schizophrenia (P<0.05),but the level of NGF-?was no significant differences in two groups of schizophrenia patients. We speculated that with positive symptoms of schizophrenia and with negative symptoms of schizophrenia may have different pathological mechanism. ?There was a positive correlation between the serum concentration of IL-1?, MBP in with negative symptoms of schizophrenia patients and the negative symptoms score of PANSS. Speculated that patients with negative symptoms is a correlation between the inflammatory state and nerve injury.The second study: ?The serum concentration of IL-1?, MBP in schizophrenia patients are significantly higher than the control group, while the level of NGF-? in schizophrenia patients are significantly lower than the control group (P<0.05). ?There was a negative correlation between the serum concentration of IL-1? in with schizophrenia patients and the WMS-III score in MCCB, while there was a negative correlation between the serum concentration of IL-1?in with schizophrenia patients and the BACS-BC score in MCCB. We speculated that cognitive dysfunction in patients with schizophrenia may be related to concentration of serum albumen factor correlation, and tell us that there is a central nerve damage and degradation performance in patients with schizophrenia.