| Aims: Recent studies suggest that polymorphisms of the TNF-α gene might be closely related to individual’s susceptibility to polycystic ovary syndrome(PCOS), but results are inconclusive. This study explored the accurate relationships between TNF-α genetic polymorphisms and PCOS susceptibility.Methods: We conducted a systematic search for articles published prior to Dec 17, 2014 on the relationship between TNF-α genetic polymorphisms and polycystic ovary syndrome susceptibility from CNKI, EMBASE, Cochrane Library, Pub Med and Web of Science database. In line with the defined inclusion/exclusion criteria, we elect the eligible studies and extract related data. We use the Stata 12.0 software to conduct the meta-analysis.Results: Ten published studies were included in the study. The pooled data suggested a dominant risk of TNF-α-1031(T/C) and-308G>A on PCOS population. For-1031(T/C): the CC/TC individuals had a high risk of developing PCOS compared to the carriers of TT genotype(OR = 1.73, 95% CI: 1.20, 2.48). Subgroup analysis by countries or study types revealed that statistical significance was found in non-Chinese but Asian, with dominant model(OR =2.16, 95% CI: 1.45, 3.21); there was no statistical significance in Chinese people, with dominant model(OR =1.35, 95% CI: 0.83, 2.20). Further subgroup analyses also suggested that dominant model was associated with increased PCOS risk in the common case-control subgroup(OR =1.99, 95% CI: 1.55, 2.54) but not in the family-based control(OR =1.07, 95% CI: 0.71, 1.59). For-308G>A: the AA/GA individuals had a low risk of developing PCOS compared to the carriers of GG genotype(OR=0.74,95%CI:0.56,1.00;P=0.047).Conclusions: The current meta-analysis could presume that TNF-α gene-1031T>C may increase the risk of PCOS, however,-308G>A might be a protect factor for PCOS. |
