A Meta-analysis On The Relation Of T950C And T245G Polymorphism In Osteoprotegerin Gene Promoter And Osteoporsis

Objective:To systematically evaluate the relation of T950C and T245G polymorphism in osteoprotegerin gene promoter and Osteoporosis.Methods:Literature were retrieved by computerized searching from Medline,Embase,CNKI, wangfang and VIP databases combined with manual searches of T950C and T245G polymorphism in osteoprotegerin gene promoter and Osteoporosis between 1996 and 2011. Literature were accessed and removed by Inclusion and exclusion criteria, included evaluate the quality of the literature by jadad score table and extract the data from literature.The statistical analysis was conducted by RevMan5.0 software.The fixed or random effect model was chosen according to the heterogeneity between the literature to merge the data. The publication bias and stability of analysis were evaluated by using funnel plot and Begg method and sensitivity analysis.Results:A total of 16 studies were included into the review,of which 11 studies related to T950C, the total sample size of 4507 from six countries; of which 9 studies related to T245G, total sample size of 3717 from five countries.The result of Meta-analysis of osteoprotegerin gene promoter T950C:1.TT genotype were found to have significantly lower spine BMD than TC and CC genotype, while no significant relation between TC and CC. The Asian Group of TT genotype were found to have significantly lower spine BMD than TC and CC genotype,while no significant relation in European Group. 2.The relationship between genotype and femoral neck BMD showed TT<TC<CC trend,which the same as the Asian Group, while not as the European group.3. Allele T was found to have significantly higher in osteoporosis group than normal group,while Allele G was found to have significantly lower in osteoporosis group than normal group.The result of Meta-analysis of osteoprotegerin gene promoter T245G:1.TT genotype were found to have significantly lower spine BMD than GG genotype, while no significant relation was found between T245G and femoral neck BMD.2. TT genotype were found to have significantly higher spine BMD and femoral neck BMD than TG+GG genotype.3. Allele G was found to have significantly higher in osteoporosis group than normal group,while Allele T was found to have significantly lower in osteoporosis group than normal group.Conclusions:T950C and T245G polymorphism in osteoprotegerin gene promoter are associated with BMD and osteoporosis,which can be the susceptible gene of osteoporosis and an useful genetic maker for studies on BMD and osteoporosis.