Preliminary Study On The Relationship Between Poor Oral Hygiene And Atherosclerosis

Objective:Poor oral health has been related with cardiovascular diseases.Specifically,periodontitis has been implicated in the pathogenesis of atherosclerosis.Our aim was to evaluate the association between poor oral hygiene and early atherosclerosis through a standardized questionnaire and carotid intima–media thickness(IMT) and atherosclerotic plaques by coronary heart disease(CHD) inpatients.Methods:202 coronary heart disease(CHD) inpatients in the central hospital of Taiyuan, from July 2014 to October 2015,were involved in the study. Demographic characteristics, oral health status, atherosclerosis risk factors and routine biochemical tests were collected using a standardized questionnaire. Carotid intima–media thickness(IMT) and atherosclerotic plaques were measured by carotid ultrasound. Patients were divided into two groups: the control group had IMT < 1mm and absence of atherosclerotic plaques, and the test group had IMT≥1 mm or the presence of any carotid atherosclerotic plaque.Results:1.One-way analysis of variance showed that in age, calculus index, the frequency of teeth brushing and tooth loss, the differences between the two groups were statistic significant(P<0.05).2.The comparison of blood lipid levels, blood lipid levels between the two groups analysis results showed that serum triglyceride, high-density lipoprotein cholesterol, total cholesterol and low density lipoprotein levels( P > 0.05), there was no statistically significant difference.3.Multivariate unconditioned Logistic regression analysis showed that calculus index(P<0.001, OR=1.864, 95%CI:1.344-2.685) and tooth loss(P<0.001, OR=1.080,95%CI:1.041-1.212) were risk factors of IMT or presence of any carotid atherosclerotic plaque.Conclusion:As calculus index and tooth loss increased, the risk of IMT thickening and atherosclerotic plaques formation increased. Calculus index and tooth loss may be the efficient risk factors of IMT thickening and atherosclerotic plaques formation.