Analysia Of The Relationship And Risk Factors Between Carotid Intima-media Thickness And Ischemic Cerebrovascular Disease

In China, cerebrovascular disease has risen to the first cause of death in China, themorbidity and mortality of cerebrovascular disease is much higher than thecardiovascular disease.The incidence, prevalence of cerebrovascular diseaseincreased year by year, is main reason for the burden of disease and rising medicalthecosts. Cerebrovascular disease can be divided into ischemic cerebrovascular diseaseand hemorrhagic cerebrovascular disease, carotid artery stenosis is an important riskfactor for ischemic cerebrovascular disease, mostly caused by atherosclerosis.Atherosclerosis is a systemic involvement arteries, especially elastic arteries ofnon-inflammatory, degenerative and proliferative disease, carotid artery is most likelyinvolving macrovascular one. More and more studies have shown that carotidintima—media thickness increased is early indicators of systemic atherosclerosis, isan independent risk factor for cardiovascular and cerebrovascular events,cardiovascular and cerebrovascular diseases are closely linked. Intima—mediathickness is early changes of atherosclerotic, plaque formation is a typical sign ofatherosclerosis, stenosis is a late manifestation of atherosclerosis progression.Subjects and methodsSunjects:Patients group:110cases suffering from ischemic cerebrovascular disease werecollected from March to July2012.The patients include60males and50females,mean age69.79±10.34;Control group:42persons with no stroke,which include13males and29females,mean age65.32±8.03. Methods:Records the gender, age, past medical history, biochemical markers, cytokines andcarotid ultrasound findingsUsing SPSS17.0statistical software,the comparison between twogroups,quanntitative data correspond to the normal distribution use t-test;qualitativedatd using chi-square test,when there is theoretical frequencies smaller than1,usefisher exact test.P＜0.05is statistically significant.ResultIn ischemic cerebrovascular disease group60malesand,50females, mean age69.79±10.34, systolic blood pressure (141.47±20.99) mmHg, pulse pressure (68.53±19.65) mmHg, glycated hemoglobin (6.24±0.95)%, high-density lipoproteincholesterol (53.78±12.79) mg/dl, homocysteine (12.08±8.298) umol/l, IL-6(5.56±3.23) ng/L; in control group13males and29females, mean age65.32±8.03,systolic blood pressure (135.31±12.08) mm Hg, pulse pressure (61.24±11.42)mmHg, glycated hemoglobin (5.82±0.63)%, high-density lipoprotein cholesterol(58.95±10.72) mg/dl, homocysteine (9.87±3.43) umol/l, IL-6(3.87±1.52) ng/l;compared as risk factors between the two groups, respectively, P=0.015, P=0.006,P=0.026, P=0.005, P=0.002, P=0.021, P=0.022, P <0.001.Divided the ischemic cerebrovascular disease group into the carotid IMT normalgroup and the carotid IMT thickening group. The group of large cerebral infarction(cerebral arterytrunk blockage caused by cerebral infarction) in the carotid IMTthickening group is51.79%,but in the carotid IMT normal group is24.07%; betweenthe two groups P=0.005. In carotid IMT thickening group37males and19females,mean age73.77±8.77,systolic blood pressure (148.81±20.91) mmHg, pulsepressure (74.73±18.68) mmHg, glycosylated hemoglobin (6.50±0.86)%,low-density lipoprotein cholesterol (94.73±24.93) mg/dl, homocysteine (13.82±9.45) umol/l, IL-6(6.48±3.88) ng/l, IL-6/IL-10(2.49±1.56); in carotid IMT normal group23males and31females, mean age65.67±10.03, systolic bloodpressure (133.94±17.72) mmHg, pulse pressure (58.46±14.37) mmHg, glycatedhemoglobin (5.98±0.98)%, low-density lipoprotein cholesterol (83.28±26.96) mg/dl, homocysteine (10.28±6.51) umol/l, IL-6(4.60±1.99) ng/l, IL-6/IL-10(1.74±0.65); compared as risk factors between the two groups, respectively, P=0.023, P<0.001, P<0.001, P <0.001, P=0.003, P=0.023, P=0.029, P=0.024, P=0.002, P=0.001.Conclusion1.Through this study we found that carotid artery atherosclerosis is an important riskfactor for ischemic cerebrovascular diseases at the same time the two share commonrisk factors,so the prevention of atherosclerosis can directly or indirectly reduce theincidence of ischemic cerebrovascular disease.2. The type of ischemic cerebrovascular disease caused by the carotid arteryatherosclerosis is mainly large cerebral infarction.3. Carotid intima—media thickness, IL-6, IL-10can be used to predict atherosclerosisand curative effection of statins.