Clinical Study Between The Number Of Missing Teeth And Carotid Artery Lesions In Coronary Heart Disease Patients

Objective:To explore the correlation between periodontal disease and atherosclerotic plaque, and guide clinical work,relevant questionnaire and oral examination was taken,carotid plaques was measured by carotid ultrasound, and biochemical indicators of blood lipid was analyzed in inpatients with coronary heart disease in this research. Methods:Unified oral questionnaire was designed.96 inpatients of cardiovascular internal medicine in Taiyuan central hospital, who was in this hospital from July 2014 to December 2014,participated in this study.65 participants was diagnosed with coronary heart disease(CHD) by medical history and coronary angiography.39 cases of them were men, and 26 cases were women.The mean age of them was 61.51±11.50 years old.In all participants,population characteristics, blood pressure, history of diabetes and cardiovascular disease, oral examination including oral health status, dental missing number and reason(excluding pulling for caries, tumors, trauma, orthodontics), and so on were recorded in detail, biochemical indicators of blood lipid including serum total cholesterol(TC), low-density lipoprotein cholesterol(LDL- C), high density lipoprotein cholesterol(HDL- C) and triglyceride(TG)were analyzed,and carotid intima-media thickness(CIMT) and plaque was measured by carotid ultrasound. Results:1. The relationship between dental missing number and occurrence rate of plaques: dental missing number and occurrence rate of plaques were analyzed by unconditioned Logistic regression analysis, OR=1.298, 95%CI: 1.100~1.531, P= 0.002,indicating that dental missing number was positively correlated with occurrence rate of plaques.2. The relationship between dental missing number and CIMT:dental missing number and CIMT were analyzed by simple linear regression analysis, the regression equation Y=0.547+0.041 X. Regression coefficient b was hypothesis tested(P<0.001), the difference was statistically significant, suggesting there is a linear relationship between dental missing number and CIMT.3. The relationship between dental missing number and plaque size:dental missing nu- mber and arterial plaque size were analyzed by correlation analysis, rs=0.519, P<0.001, the difference was statistically significant, indicating there is a relationship between dental missing number and the diameter of the plaque.4. The relationship between dental missing number and blood lipid:dental missing number and blood lipid levels were analyzed by Kruskal Wallis H-inspection, the difference was not statistically significant(P > 0.05). Conclusions:In the participants(inpatients with coronary heart disease),with the increaseof dental missing number, the occurrence rate of carotid plaques increased, the carotid intima-media thickness increased, the diameter of the plaques also increased.Namely: dental missing number was positively correlated with occurrence rate and size of carotid plaques;dental missing number due to periodontal disease may be an important risk index of atherosclerotic disease.