| Transient Ischemic Attack(TIA)is one of the most common acute cerebrovascular disease.Due to the increase in multiple pressure such as society,life,more and more TIA paients appear.The cause of disease is associated with a variety of factors,such as the change of blood components, hemodynamic changes,the occurrence of atherosclerosis,and so on.According to the involvement of TIA patients with different artery can be divided into the internal carotid artery system TIA and vertebral-basilar artery TIA.Internal carotid artery system in TIA patients with hemiplegia and partial body feels obstacle and the contralateral homonymous hemianopia,aphasia,disuse, personality and emotional disorder,the contralateral limb weakness,etc. Vertebral-basilar artery system of TIA patients often appear dizziness,balance disorders,abnormal eye movements,diplopia,also can appear one or both sides and mouth weeks of numbness,with or without contralateral limb paralysis and sensory disorder clinical manifestations.Depression as one of the most common mental illnesses,also appears a trend of increasing,negative emotions not only affects the patient’s daily work and life,also can affect the health of patients,making patients with heart cerebrovascular diseases,cancer and other diseases.TIA patients,because of its long endure suffering often merge depression,depressive symptoms always can make the original TIA symptoms worsen,and cause the disease prognosis of patients with adverse,seriously affect the patient’s quality of life.Many studies found that the occurrence of TIA closely associated with carotid atherosclerosis,and depression has also been confirmed associated with carotid atherosclerosis.Carotid intima-media Thickness(Intima-media Thickness,IMT)for many years has been studies associated with carotid atherosclerosis.To a certain extent,it can be used as a reaction index of the degree of atherosclerosis.The study aimed to explore the TIA patients with depression and the relationship with carotid IMT,designed to show that attaches great importance to the monitoring of patients with carotid IMT monitoring.For improving the prognosis of patients with emotions and TIA,it has important clinical significance.Objective:Research merge depression in patients with transient ischemic attack,the relationship between carotid intima-media thickness of carotid intima-media thickness thickening merge depression in patients with transient ischemic attack.Methods: 1.Case choice:In April 2014 to December,chengde medical college affiliated hospital of geriatrics department in hospital,120 cases with vertigo to starting symptoms,and in accordance with TIA patients with diagnosis of vertebralbasilar artery system as the research object,in which 59 patients with TIA merge depression as the observation group,61 patients with TIA was not merge depression to the control group. 2.Two groups of patients with carotid artery IMT measurement:Application of the CE-VIVID7 color doppler ultrasonic diagnostic instrument,measurement of carotid artery in patients with distal bifurcation 1cm,1cm between internal carotid artery and carotid sinus of IMT values,take the average of the three, and record for the patient’s carotid IMT values.According to the evaluation criteria will carotid IMT<1mm record for normal endometrium,IMT acuity1.0 mm or plaque formation records for intimal thickening. 3.Sign all patients with Anxiety Depression Scale(Anxiety and ’Scale, HAMD) score.According to the scoring criteria,score<20 points records as normal, score 20 points or more records as depression. 4.Record the factors associated with TIA:Record the patients’ age,sex,body mass index(BMI),low density lipoprotein(LDL-C),and whether a history of hypertension,coronary heart disease and diabetes and other clinical indicators. 5. Statistical analysis:Using SPSS19.0 for statistical analysis.Comparison between groups using single factor analysis of variance and rank or inspection; Count data by chi-square test;After the correction of risk factors,the use of Logistic. P for the difference was statistically significant.Result: 1.The comparison of two groups of patients with carotid artery IMT:Carotid IMT(1.58±0.77)mm in observation group,carotid IMT is significantly higher than control group(0.94±0.27)mm.With significant difference(P< 0.001),and statistical significance. 2.Compare two groups of patients with other risk factors:the observation group and the onset of hypertension(48/81.36%),the onset of hypertension is significantly higher than control group(37/60.66%); Observation group the onset of coronary heart disease(22/37.29%), the onset of coronary heart disease is significantly higher than control group(12/19.67%); Observation group the onset of diabetes(27/45.76%), significantly higher than control group in the onset of diabetes(16/26.23%); Observation group LDL-C value is(2.56±0.78) tendency for L, LDL-C value is significantly higher than the control group(2.30±0.62) tendency/L. The differences were statistically significant(P < 0.05). 3. The observation group of patients with carotid artery IMT thickening(50/84.75%), higher than that of control group(22/26.07%), P<0.001, the difference is statistically significant. 4. Logistic regression analysis showed that the thickening of the carotid IMT and TIA patients is closely related to depression, and after adjustment of age and the cerebrovascular disease risk factors still exists the difference(P<0.05).Conclusion: 1. The carotid IMT thickening is one of the important risk factors for patients with TIA merge depression as a result, the effective intervention of atherosclerosis, control of TIA patients with carotid IMT thickening, the prevention and treatment of patients with TIA merge depression has important clinical significance. 2. Effective prevention and control of hypertension, coronary heart disease, diabetes, patients with control blood LDL-C level, has important clinical significance for prevention and control of TIA patients with depression. 3. Pay attention to the spirit of TIA patients after condition, merge depression in patients with prevention, improve the patient’s quality of life and the progress of the TIA outcome has important clinical significance. 4.Attaches great importance to the patients with carotid artery IMT monitoring to prevent the occurrence of coronary heart disease,reduce acute cardiovascular events has important clinical significance. |
PDF Full Text Request