The Expressions And Clinical Significance Of OCT4, STAT3 And E-cadherin In Ovarian Serous Or Mucinous Cystadenocarcinoma

[Objective] 1. To explore the expression of OCT4,STAT3 and E-cadherin in serous or mucinous ovarian serous or mucinous cystadenocarcinoma and their relationship. 2. To explore the relationship between OCT4,STAT3 and E-cadherin in ovarian serous or mucinous cystadenocarcinoma.[Methods] The expressions of OCT4,STAT3 and E-cadherin were detected by tissue microarray combined with situ hybridization, S-P immunohistochemistry in ovarian serous or mucinous cystadenocarcinoma.[Results] 1. The positive expression rates of OCT4 were35.0%(7/20)in ovarian serous or mucinous cystadenoma less than the 83.3%(50/60)in cystadenocarcinoma. There was significant difference between them(P<0.0001)But the rate of OCT4 expression in carcinoma was not associated with histologic types, grade and lymph node metastasis(P>0.05). 2. The positive expression rates of STAT3 were35%(7/20)in ovarian serous or mucinous cystadenoma less than the71.6%(43/60)in cystadenocarcinoma. There was significant difference between them(P<0.05). The rate of STAT3 expression in carcinoma of gradeⅠ,Ⅱwas lower than grade Ⅲ,Ⅳ(P<0.05). The positive expression rates of STAT3 were evidently higher in moderately and poorly differentiated carcinoma than that of the well differentiated group(P<0.05),and was not associated with histologic types, but was related to lymph node metastasis(P<0.05).3. The positive expression rates of E-cad were90%(18/20)in ovarian serous or mucinous cystadenoma higher than the 16.7%(10/60)in cystadenocarcinoma. There was significant difference between them(P<0.05). The rate of E-cad expression in carcinoma was only related to lymph node metastasis(P<0.05) when others were opposite. 4. In ovarian serous or mucinous cystadenocarcinoma, there was a significantly positive correlation between OCT4 and STAT3 expression(P<0.05), but on the other hand there was a significantly negative correlation both of STAT3 and OCT4 to E-cad(P<0.05).[Conclusion] THE overexpression of STAT3 and OCT4 may play an important rote in the development and progression of ovarian serous or mucinous cystadenocarcinoma, so as the degree expression of E-cad,and each other and may play a synergistic effect.