Analysis Of Clinical Featurees And Prognosis Of The Colorectal Neoplasm Patients With Concomitant Metabolic Syndrome

Objective:To investigate the clinical features of colorectal neoplasm patients with concomitant metabolic syndrome (MS).Methods:A retrospective analysis was based on collecting the clinical data of 107 patients who were admitted to hospital and diagnosed as colorectal neoplasm with MS(group A) and 230 colorectal neoplasm patients who without MS (group B) since May 2012 to May 2015.Results:Compared the two groups:on the male incidence:72 cases (87.3%) group A Vs 125 cases (54.3%) group B, the difference was statistically significant (P< 0.05); compare to Onset age:(group A) 66.28 ±10.72 vs.(group B)55.82±13.87, the difference was statistically significant (P< 0.05);And about risk of location, on left hemicolon was (group A) 55 (76.4%) VS (group B) 61 (54.3%), on rectum was (group A) 35 cases (32.7%) VS (group B)112 cases (48.7%), the difference was statistically significant (P< 0.05);as to the metabolic components analysis between the adenomas and colorectal cancer in MS group, low high-density lipoprotein (HDL-C) reduce 53 cases (29 cases 72.5% vs. 72.5%) there was no statistically significant difference (P> 0.05), and elevated triglycerides (TG) 45 cases (14 cases of 35% vs.35%) difference was statistically significant (P< 0.05), while the patients appeared high TG and low HDL-C leel:27 cases (40.3%) vs.17 cases (42.5%), there was no statistically significant difference (P> 0.05);On two groups of patients with Hcy and tumor markers in serum content of comparison, display higher Hcy for 18 cases (16.8%) VS.13 cases (5.7%), elevated CA125 21 cases (19.6%) vs.15 cases (6.5%), tumor markers for more than 2 items and at the same time rise in 21 cases (19.6%) VS.24 cases (10.4%), the difference had statistical significance (P< 0.05), while the CEA, CA199 in two groups of patients with elevated situation has no obvious difference; at last, as the follow-up results showed in metabolic syndrome in patients with colorectal cancer that 20 cases had metastatic, and 24 cases of death, by Kaplan-Meier’s estimate showed the median survival time was 31 months, compared with the control group (38 months), statistically significant difference (P< 0.05).Conclutions:The colorectal neoplasm patients with concomitant metabolic syndrome are always diagnosed in old-age male, and the left hemicolon; the high level of TG may play a role in the process of colorectal adenomas develop to colorectal cancer, and joint detection of multiple tumor markers can be used to predict the early diagnosis of benign or malignancy in these patients,and always with bone, liver -lung and peritoneum for common metastatic sites and the poor prognosis of it.