Study On The Relationship Between The Postprandial Serum Triglyceride Levels And Artery Elasticity In The Patients With Hypertension Or Metabolic Syndrome

Objective To explore the change of postprandial serum triglyceride levels after a single high-fat meal, and to investigate the relationship between postprandial serum triglyceride levels and small and large artery elasticity. To reduce cardiovascular accidences of the patients with hypertension and metabolic syndrome.Objects and Methods There are thirty fore patients with essential hypertension and thirty two patients with the metabolic syndrome(defined by the Adult Treatment Panel III) in hospital from No.2 hospital. There are thirty fore healthy controls were studied. We prospectively studied 100 patients who were submitted to a standardized fat meal (FM) test(800 calories 50g fat).The concentration of triglyceride, total cholesterol, LDL cholesterol, and HDL cholesterol in fasting serum and at 4 hours after a single high-fat meal were measured. Small and large artery elasticity was assessed in the brachial artery by the HDI/Pulsewave CR-2000 Research CardioVascular Profiling Systems before and after 4 hours of high-fat meal. Statistic analysis used t-test, Chi-Suuare, and multiple Linear Regression.Result (1) No significant difference in fasting lipid levels, age, and sex among three subjects was found. There were hypertension in patients(P>0.05), and there were low high-density lipoprotein (HDL) cholesterol levels and elevated plasma glucose in patients with metabolic syndrome. Fasting C1,C2 had been injured in patients with hypertension or metabolic syndrome(P<0.05). (2) Compared to normal subjects the patients with hypertension or metabolic syndrome had higher serum triglyceride levels at 4 hours after a high-fat meal (P<0.05), the metabolic syndrome patients hadthe highest serum triglyceride levels (P<0.01). The postprandial artery elasticity were impaired more seriously in patients than in controls (P<0.05). The postprandial large artery elasticity were impaired more seriously in patients than in controls (P<0.05). (3) No significant difference in arterial tension,pulse between fasting and postprandial subjects ( P>0.05 ) . Compared to the fasting serum triglyceride levels the postprandial serum triglyceride levels increased significantly at 4 hour in all subjects(P<0.05). The postprandial small artery elasticity impaired significantly after a high-fat meal in three groups (P<0.05). The degree of severity of postprandial artery elasticity was most serious in patients with metabolic syndrome(P<0.01). (4) The increase in 4 hour serum triglyceride level was correlated with the degree of impairment of postprandial artery elasticity.Conclusions The postprandial hypertriglyceridemia in patients induced significantly impairment of postprandial artery elasticity, the patients with metabolic syndrome had more risk factors had the highest postprandial serum triglyceride levels which induced the most significantly impairment of artery elasticity. So the patients with metabolic syndrome had higher risk of artery atherosclerosis.