| ObjectiveThe paper selects the deficiency type of chronic asthmatic bronchitis patients as the research subjects. Observe whether applying Tianjiu therapy can promote the patients’ symptoms ease or disappear in exactly the same western medicine standards, thus improve the clinical curative effect and enhance the quality of life of patients. In recent years, with the increasing aging population and the degree of air pollution, the number of patients suffering from chronic asthmatic bronchitis in our country is increasing, which seriously affects people’s daily work and quality of life. Xiaohaizi Reclamation is one of the three division of Xinjiang southern production and construction corps, belongs to an arid desert climate.It has a large temperature difference between day and night and frequent dust storms. Due to the perennial wind and cold air, chronic asthmatic bronchitis has already become one of the most common diseases of the local. Therefore, to treat the disease by studying a more efficient methods, is of greater importance to improve the efficacy of this disease. And Tianjiu therapy for this disease is simple, non-toxic side effects and acclaimed.MethodsCases of this clinical study were collected from the outpatients of Xinjiang Tumushuke City People’s Hospital, diagnosed as "chronic asthmatic bronchitis".All of the 100 patients were meeting the inclusion criteria. According to the ratio of 1:1 allocation,100 cases of chronic asthmatic bronchitis patients were assigned to the treatment groups (Tianjiu group) and control group (placebo group) on average, by using the method of randomized controlled trials. The foundation treatment of these two groups is exactly the same:Therophylline, oral, each time 0.1g,2 times a day, morning and evening, taking 5 consecutive weeks.The treatment group will use Tianjiu therapy on the basis of foundation treatment. The Tianjiu paste is containing fumaric, Mustard Seed, Asarum, euphorbia and some other drugs. The Department of pharmacy of Tumushuke City People’s hospital is responsible for providing, dispensing, cleaning, crushing the drugs into fineness 80 mesh powder and mixed powder uniformly. All the acupoints were selected from the following three groups of acupoints alternately, and each acupoint was selected on both sides:(1)Fei shu(both), Wei shu(both), Zhi shi(both), Dan zhong; (2) Feng men(both), Pi shu(both), Gao huang shu(both), Tiantu; (3)Ding chuan(both), Shen shu(both),Xin shu(both)、 Zhong wan. Then we reconcile the ginger and the powder above into a cream powder(powderand ginger weight ratio of 3:4), and cut the cream powder into about 1cm×1cm×1cm-sized drug blocks, let the patients take seats, then clamp the drug blocks placed in about 5cm×5cm entilation tape and affixed to the acupoint, tear off the tape by subjects after enough time.The control group will use placebo on the basis of foundation treatment. The placebo is mixed by buckwheat flour, chestnut shell brown pigment powder and red yeast rice powder on a ratio of 6:3:1. Then we reconcile the ginger, water and the placebo into a cream powder(water ginger weight ratio of 10:1) to make it is similar to the Tianjiu paste in appearance and texture. Then proceeded as the treatment group.Two above groups of subjects were treated 3 times a week for a total of 15 treatments. The duration of each fixation was 2h and each treatment interval was more than 48 hours. If the treatment completed for more than 12 times (including 12), it will be regarded as the completion of the whole treatment.Efficacy evaluation:The TCM syndrome total score and Asthmatic bronchitis quality of life questionnaire scale were adopted as the indexes of efficacy evaluation; keeping records of adverse events and side effects occurred at any time during the study. SPSS19.0 statistical software was applied to build a database for processing and analysis.Results1 Baseline dataAfter statistical test, the differences of the race, gender, age, course of disease in these two groups of subjects were not significant (P=0.086% 0.248、0.103、 0.064). Before treatment, the scores of traditional Chinese medicine syndrome and asthmatic bronchitis quality of life in these two groups of patients were equivalent (P=0.838、0.052). It proves that the baseline data is comparable between the two groups.2 TCM syndrome scoreThe treatment group:Before treatment group, at the ninth treatment, at the end of the treatment, TCM syndrome scores were 9.04±1.43、4.68±1.42、 1.84±2.15. The scores of each time point were compared with those before treatment respectively, P< 0.05, proving that the differences were significant.The control group:Before treatment group, at the ninth treatment, at the end of the treatment, TCM syndrome scores were 8.98±1.49、5.94±1.54、3.72 ±2.22. The scores of each time point were compared with those before treatment respectively, P<0.05, proving that the differences were significant.Through Independent samples t-test,TCM syndrome scores of two groups among each time point were significantly different, P<0.05.3 AQLQ scoreThe treatment group:Before treatment group, at the end of the treatment, AQLQ scores were 105.04±22.76、204.82±20.03. The scores of each time point were compared with those before treatment respectively, P<0.05, proving that the differences were significant.The control group:Before treatment group, at the end of the treatment, AQLQ scores were 113.70±21.26、158.26±21.21. The scores of each time point were compared with those before treatment respectively, P<0.05, proving that the differences were significant.Through Independent samples t-test, AQLQ scores of two groups among each time point were significantly different, P<0.05.4 Effective rateAfter statistical test, the qualified subjects in the treatment group and the control group were 50 cases each. The total effective rate of the treatment group was 92%, while the total effective rate of the control group was 74%. The comparison of the two groups’curative effect is belonging to two independent samples comparison level data, we use rank sum test to detect get P< 0.05,proving that the differences were significant.ConclusionIn summary, Tianjiu therapy has better curative effect on improving the clinical symptoms of chronic asthmatic bronchitis.At the same time, it can significantly improve the quality of life of patients with asthmatic bronchitis, it’s worth to be popularized in clinic. |
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