The Clinical Research Of Interferon Atomization Inhalation In The Treatment Of Respiratory Syncytial Virus Asthmatic Bronchitis

BackgroundAsthmatic bronchitis is common throughout the world, the most common ininfants and young children period, often showed a trend of recurrent episodes,andhave correlation with respiratory virus infection, about more than half have breathingattack of infants and young children to6years old can completely stop attacks, somespecific constitution of children in the future has the potential to develop asthma, atthe same time, the majority of children with asthmas attack breathing is also inpreschool for the first time, this is basically the same age and respiratory virusinfection.The respiratory syncytial virus (RSV) has been confirmed that is one of thecommon virus which causes infant wheezing onset.At present, the virus infectioncaused wheezing become the possibility of bronchial asthma is increasing, especiallyfor recurrent wheezing, its incidence is nearly10times as much as those with nosymptoms of wheezing.So the correlation between the virus and wheeing get moreand more attention of people.Therefore, according to the characteristics of childrenwith different clinical condition carefully observe and early interventional treatment,will have of great significance to reduce the incidence of bronchial asthma in thefuture, and also have the important measures to improve the health status of infants and young children.However, the current lack of infant asthma clinical earlydiagnosis standard, nor point out the necessity of early preventive treatment objectivebasis, the reason may be that the current lack of viral infants and young children thecomprehensive understanding of the pathogenesis of chronic airway inflammationand effective method for clinical judgement.In recent years, the incidence of childrenwith asthma on the rise, it will seriously affect the children’s physical and mentalhealth.Most children with asthmatic bronchitis can occur repeated wheezing, and evenasthma.Wheezing will induce due to acute upper respiratory tract infection, thefrequency of recurrent and prognosis is associated with family genetic factors andenvironmental factors.Asthmatic bronchitis induced specific mechanism may becaused by a virus respiratory epithelial cells secrete a large number of inflammatorymediators cause respiratory high reaction, make the bronchial mucosa edema,increased mucus secretion, bronchial smooth muscle spasm, causing respiratory tractstenosis causing breathing.RSV is still one of the major hot spots in the study, most children at least haveonce RSV infection before the age of3years old.RSV caused bronchiolitis mainly ininfants and children under the age of1year old.There is no direct research evidencecause-and-effect relationship between RSV and asthma, in a large sample oflong-term study found that children born with respiratory virus epidemic peak(especially the RSV) has the relationship between independent predictor of asthma,born in about4months before the peak virus epidemic season will be a high riskfactor for asthma in children.In addition, the resistance to RSV immunoglobulin canreduce the incidence of asthma and allergic disease, reduce the occurrence ofbreathing repeatedly, also can improve the lung function of chronic airway disease inchildren.Prevention and control of RSV infection can improve asthma childrenbreathe and immunological indexes.But not every RSV infection children have takenplace in the breathing, so the factors such as heredity, environment, growth anddevelopment may also play an important role in the development of asthma disease.At present, one study of the relationship between asthma and theearly infection in the early of childhood, found that the virus infection and childhood airway allergic asthma in chronic airway inflammation and the formationof secondary in the formation have the synergy, and virus infection in infants andyoung children period has the correlation between persistent wheezing and asthmain preschool.So, virus infections and respiratory allergic both through differentmechanisms leading to the occurrence of airway dysfunction.On the one hand, thevirus destroys the airway epithelial barrier function, makes the body’s absorption ofallergen relative increase;On the other hand, the increase of inflammatory cytokines,leukotriene, inflammatory molecules and chemical factors increased the accumulationof inflammatory cells, activation, that causes the airways sustained immune response.ObjectiveThe clinical research of joinning Interferon atomization in the treatment ofrespiratory syncytial virus asthmatic bronchitis.MethodsThe object of study for sep2012to July2013in our hospital80cases of childrenwith asthmatic bronchitis,46cases of male, female34cases. Using randomized,controlled method selected children can be divided into the treatment group40casesand control group40cases, two groups are the conventional treatment methods,including expectorant, and asthma, allergy symptomatic treatment, giving oxygenwhen necessary, with bacteria infection gives anti-infection treatment. The controlgroup given budesonide, terbutaline aerosol inhalation,2times a day, treatment7days; Treatment group40cases in the control group based on atomization andinterferon alpha1b1ug/Kgd, divided into2times, the course of7days. Clinicalobservation and record two groups of wheezing disappear time, cough disappeared,my lungs then disappear time, average hospitalization days.Results1. The treatment group and control group in age, sex, course prior to admission,and general information on aspects of contrast had no significant difference (P>0.05).2.Clinical manifestation of cough with breathing (100%), lung auscultationaudible and wet rale (91%). Two groups of children with clinical comparison therewas no significant difference (P>0.05). 3. The treatment group with clinical main symptoms remission rate was betterthan control group, the average hospitalization days treatment group (7.25±1.59)days, the control group (8.90±2.87) days, are similar between the two groups havestatistical significance (P＜0.01). Two groups of curative effect comparison showefficiency is82.5%in treatment group, control group efficiency62.5%, the twocomparative difference was statistically significant (P＜0.05).4. And the two groups had no local irritation, rash, fever, vomiting and otheradverse reactions occur.ConclusionShort-term combined interferon atomization inhalation to improve condition andcourse of respiratory syncytial virus asthmatic bronchitis effect is remarkable, is aneffective means to clinical anti-infection therapy, interferon atomization method iseasy to accept for children, non-toxic side effects and treatment process.Interferoneconomic security, the effect is obvious, it is worth clinical promotion.