| Objective:1.To establish the peak bone mass density and investigate the changes of the database of Dai Nationality in Dehong city Yunnan province 2. To investigate the osteoporosis prevalence of the Dai people in Dehong and to explore the risk factors.3. Using OSTA system perform the osteoporosis self-diagnosis and prediction for the target population, and using FRAX system to predict the osteoporotic fracture rates so that to provide reference for self-screening and risk prediction for Dai people in Yunnan Province.4. To Determinate osteoporosis and serum markers of bone metabolism of Dai nationality over the age of 40,and investigate its changes.Methodsr:1. Using cluster sampling method, extract 160 people in Dehong city, including 49 cases of males.111 females, the age from 20 years to 77 years, according to criteria grouped into a 10-year-old age group and divided 6 gruops. Performing the test by quantitative ultrasound (including the calcaneus BMD values, T value, SI value), and collect the basic information, osteoporosis-related factors from the volunteers after that calculate patient OSTA index, FRAX score, and do the statistica analysis.2. By random sampling method, selected 105 Dai nationality people over the age of 40, aged 40～77 years, were divided into 4 groups according to age, serum markers of bone metabolism in 25-Hydroxy Vitamin D3、PTH 、Osteocalcin(Bone Gla Protein)、Calcitonin (CT) and NTX by ELISA method, and analysis the the detection results.Results:1.In the 160 people, the BMD and SI value in 20 to 29 years age group is the highest, respectively BMD=0.57±0.10 g/cm3, SI=108.87±24.17, with the declining of the bone mass, the group of 60 -69 years is the lowest, in which the BMD and SI of 30 to 39,50 to 59,60--69 age groups lost most rapidly and with statistical significance.2. There are 23 people suffering from osteoporosis in 160 Dehong Dai populations, the prevalence rate (PR) was 14.4%, which the PR men:12.2%; PR women:15.3%; 63 Osteopenia,39.4% of the total rate. Gender has a direct impact on the OP prevalence study population, Dai OP prevalence in women than it in men, the loss of bone mass has the same result. For all groups, the study revels that the PR of male and female in 50-59,60-69 ages is much higher than in other age groups, and the bone loss rate is higher than the other ages.3. The age, height, waist circumference compared with the BMD, SI, T value was for the negatively correlated, and BMI, OSTA index is positively correlated with BMD, SI, T value.and the other is no significant meaning.4. The OSTA value and the risk level is positivly correlated with OP prevalence, the higher of the risk level in OSTA and the higher the PR is in Dai people.5.The OR value is 19.49 in fruture factor, which the fracture history occurred previously Dai people osteoporosis than those not over 11.86 times higher. The remaining factors was not statistically significant.6. There are 137 people whose age over 40 in 160 people, predicting the probability of systemic osteoporotic fractures in the next 10 years was 4.54±2.15%, the hip fractures was 0.72±1.11%. the 50-59、60-69 year old female osteoporotic fracture probabilities were significantly higher than other groups, the probability of occurrence of osteoporotic fractures in 60-69 year-old group of male than other age groups, with statistical significance.7. The average content of the 25-(OH) Vit D3 in Dai people over the age of 40 is 25.67ng/ml, PTH:37.19pg/ml, BGP:6.53ng/ml. CT:41.91pg/ml. NTX: 59.75ng/ml. there was significant difference between the 60 to 69 age group for men and women of the NTX content comparison; 25-(OH) Vit D3 content in70 to 79 years of age compared with the the other age is declined sinificantly. there are significant differences between the 60 to 69 age group for men and women statistically significant contrast CT content.Conclusion:1. Female (Lack of the male 20～29 age group) PBMD appeared in the 20～29 ages. The male SI peak in 20～29 ages, the result is consistent with most of the country, compared whit the mean bone volume than other regions 5 in which 50～59 years, 60～69 year～age group lost rapidly, which has become the important time for prevention and treatment of osteoporosis.2. The OP prevalence population in Dehong Dai people is higher than the national average value, and the coastal cities and economically developed areas is higher than that, we can refer to its specific diet and lifestyle, conclud that it is the high incidence of osteoporosis in Yunnan province. The future of osteoporosis knowledge popularization, advocacy in this area should be focus on it.male in 60 to 69 years old and female in 70 to 79 years has the high PR, so we should strengthen the Dayton Dai population screening for osteoporosis treatment selected to the golden age, to improve the prognosis of patients.3. Age, BMI is one of the factors of osteoporosis, we should focus on it. The brittle fracture is the important factors of the osteoporosis, we should pay more attention to osteoporosis prevention of brittle fracturer.4. OSTA systems for the BMD values and SI values have good correlation, so that it can be used for preliminary screening of Dehong Dai with osteoporosis. It is a good method for the remote mountainous areas, where there are no bone density test conditions. It requires only a few simple physiological indicators we can achieve for the Undeveloped Minority Regions osteoporosis preliminary screening.5. We use the FRAX score to predict the probability over the age 40 in the next 10 years found that it has higher probability of hip fracture in 50-59 years,60-69 years.so we should be targeted at those ages literacy and prevention, to truly reflect the three prevention strategies in disease.6. With the age incressing, the male, female serum 25-(OH) Vit D3 content is gradually declining. The parathyroid hormone levels gradually increase, but fluctuations in the 50-59 age group. The CT decreased with age, but the NTX is increased, which only NTX among the age group and there are significant differences between men and women 60～69 years of age compared with the the others. We believe that NTX as a sensitive indicator, there is a clear guidance and NTX can be further extended to detect detection of bone metabolism markers.we can use it to further osteoporosis diagnosis, treatment and prognosis. |
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