Initial Probe Of Influential Factors Of Bone Biochemical Markers In Infants

Objective: In order to probe the factors affecting bone turnover in healthy infants, we investigated the correlations among the bone biochemical markers, height(H), weight(W) and body mass index(BMI) in participants younger than 36 months.Methods: One hundred and twenty healthy infants (younger than 36 months, with half males) were recruited and divided into ten different groups according to age and sex. The height and weight of all infants were recorded and fasting venous blood sample were collected. Serum concentration of bone-specific alkaline phosphatase (bALP) and tartrate-resistant acid phosphatase (TRAP-5b) were measured. All data were imputed into SPSS 11.0 for statistical analysis.Results: 1. The level of bALP/H and bALP/H³ were correlated with age and weight. The coefficient corcorrelated in male with age and weight were: R_H,age= - 0.540, R_H,weight=-0.463, R_H³,age= - 0.702 and R _H³,weight= -0.690; the coefficient corcorrelated in female with age and weight were:R_H³,age= -0.690, R_H³,weight= -0.546, R_H³,age = -0.826, R_H³,age= -0.643. 2.In male, the level of TRAP-5b/H and TRAP-5b/H³ were correlated with ageand weight. The coefficient corcorrelated were: R_H,age=- 0.375, R_H,weight=- 0.354, R_H³,age=-0.555 and R_H³,weight= - 0.573. 3. The level of bALP and TRAP -5b had no correlation with age, height, weight and body mass index in male and female. 4. The level of bALP/H, bALP/H³, TRAP-5b/H and TRAP-5b/H³ had a negative correlation with age and weight and were declined with increasing of age and weight.Conclusion: 1. The levels of bALP and TRAP-5b had no correlation with age, height, weight and body mass index in infants. 2. The level of bALP/H, TRAP-5b/H, bALP/H³ and TRAP-5b/H³ were negative correlated with increasing of age and weight. The clinical value of the results needs to be advanced studied in future.