Association Between IL-10 Gene Polymorphisms And Risk Of Recurrent Spontaneous Abortion:a Meta-Analysis

Objective:To evaluate the association between interleukin-10 (IL-10) gene polymorphisms and risk of recurrent spontaneous abortion (RSA).Methods:Literatures published on PubMed, Cochrane Library, CKNI, WANFANG DATA and CBM were searched based on the established strategy.Quality of included studies was assessed,the analysis of heterogeinety between the included studies was performed.ORs and their 95%CI were used to assess the strength of association between IL-10 gene polymorphisms and risk of RSA. Stata 12.0 was used to analyze the data.Results:A total of 13 case-control studies were eligible for the meta-analysis. Among these studies,ten studies with 1125 cases and 1204 controls studed on rs 1800896, five studies with 880 cases and 787 controls studed on rs 1800871, six studies with 904 cases and 823 controls studed on rs1800872.Our meta-analysis suggests insignificant association between rs 1800896 polymorphism and risk of RSA,with (OR=1.02,95%CI: 0.91-1.15),(OR=1.17,95% CI:0.97-1.42), (OR=0.95,95% CI:0.79-1.16) under allele, dominant and recessive genetic models,respectively. In the rs 1800871 polymorphism, the heterogeneity analysis shows that except the codominant model (CT vs. TT) I2 is less than 75%, the remainder of the risk model heterogeneity analysis shows that I2 are above 75%, indicating that there is considerable heterogeneity among the study variables, suggesting that results with low confidence, the data cannot be merged. But women with allele A or genotype AA in the rs 1800872 polymorphism have higher risk of RSA,with(OR=1.33,95%CI:1.14-1.55),(OR=1.36,95% CI:1.12-1.67), (OR=1.53,95%CI:1.13-2.09) under allele, dominant and recessive genetic models,respectively.Conclusions:IL-10-1082G/A(rs 1800896) polymorphism is not significantly associated with the risk of RSA, whereas-592C/A(rs 1800872) polymorphisms show significant associations with RSA. Women with allele A or genotype AA in the-592C/A(rs 1800872) polymorphism have higher risk of RSA. It provides an important basis for the prevention, diagnosis and gene targeted therapy in the future.