Clinical Research Of Wenjing Tang On Perimenopausal Female With Chronic Insomnia Belonging To Type Of Cold Coagulation And Blood Deficiency

BackgroundAs a special class of people, due to ovarian dysfunction and dramatic changes in sex hormones, and changing of social relationships, perimenopausal women arise a series of physical and psychological symptoms. Among these symptoms, insomnia is one of the most common symptoms affect life.In clinical, Professor Yang Zhimin founded that there is a part of women who suffer peri menopausal period but without typical symptoms of menopause syndrome (such as the hectic fever, night sweats). They characterized in cold limbs, Local cold and pain, pale or yellow complexion, deep thready pulse and so on, as we called "Cold Coagulation and Blood Deficiency".By treatment method of expelling pathogenic cold from channel and nourishing blood and dredging collaterals, such as the fuction of Wenjing Tang, these type of patients can improve their quality of insomnia.MethodsIn outpatient of Guangdong Hospital of Traditional Chinese Medicine between April 2015 to January 2016,30 women were selected who were diagnosed insomnia and between 41-59 years old. Wenjing Tang were given to these subjects for 1 month.Before and after the intervention, researcher evaluated subjects in these sides below:subjective sleep quality rat ing:Pittsburgh Sleep Quality Index Scale(PSQI), emotional self-rating scale assessment:Self-Rating Depression Scale(SDS), self-Rating anxiety scale(SAS), quality of Life:the amount the world Health Organization Quality of Life Form(WHOQOL-BREF).Result1.Subjective sleep quality(1)reduction rate of PSQI score:In this study, After intervening of Wenjing Tang,4 cases (13.3%) were clinical cured and 3 cases (10.0%)were markedly effective, also 12 cases(40.0%) were effective,but 16 cases(53.3%)were ineffective.(2) total efficiency of PSQI score:After intervention of Wenjing Tang, there were 19 people had effections, and the total effective rate was 63.3%.(3)changes of PSQI factor scores after intervening:In the study of intervention of Wenjing Tang, PSQI total score and six factors scores, which includes subjective sleep quality, Sleep latency,sleep efficiency,sleep disorders,sleep aids drugs, daytime function, these all decreased than scores before treatment and the differences were statistically significant (p＜0.05). Score of sleep duration was drop, but the differences had no statistical significance(p＞0.05).2. Emotional stateAfter intervention of Wenjing Tang, SDS, SAS scores of subjects all reduced and that differences were statistically significant (p＜0.05).3. Quality of lifeAfter intervention of Wenjing Tang, total score of WHOQOL-BREF and scores of three factors(field of physiology,field of psychology, field of environment)all decreased and the results with statistical significance(p＜0.05). The score of field of social relations after intervention was decline,but it had no statistical significance(p＞ 0.05).4.Ineffective groupAccording to PSQI reduction rate, the subjects were divided into effective group and the ineffective group. After intervention of Wenjing Tang, SDS, SAS scores of ineffective group were reduced and the differences of SAS scores were statistically significant(p＜0.05).After intervention of Wenjing Tang to the ineffective group, total score of WHOQOL-BREF and scores of there factors(field of physiology, field of social relations, field of environment) all decreased and the results with statistical significance(p＜0.05).5.Symptoms and efficacyThe single factor exploratory analysis was carried out on the difference symptoms between the two groups. Curative effect and symptoms of usually afraid of cold, fatigue, hypomenorrhea, distending pain of breast and pars costalis were positively correlated. And Curative effect and symptoms of irritable, dry tongue, moss water, using of sleeping medicine were negatively correlated.Conclusion1. Wenjing Tang not only can improve subjective sleep quality and adjust emotional state, such as depression and anxiety symptoms, but also can improve quality of life in on perimenopausal female with chronic insomnia who belonging to type of cold coagulation and blood deficiency.2. For the ineffective group, Wenjing Tang also has a clearly effect to improve the stress, anxiety symptoms and the quality of life.3. For chronic insomnia patients in the peri menopausal period, Wenjing Tang will has a good curative effect in patients who meet the symptoms of usually afraid of cold, fatigue, hypomenorrhea, distending pain of breast and pars costalis, and at the same time, excluding symptoms of irritable, dry tongue, moss water,using of sleeping medicine.