Clinical Research In Cys-c Of Jiangtang Baoshen No.1 Recipe Treating Diabetic Nephropathy(Ⅲ Stage)

Background About 20%-50% of type 2 diabetes patients occur to diabetic nephropathy (DN).Diabetic nephropathy is one of the most severe diabetic microangiopathy complications.It is the most common cause of end-stage renal disease in the United States and Europe,according to statistics as high as 44.5%,accounting for about 15% in china.The incidence of diabetic nephropathy in hospitalized patients with diabetes in China was 33.6%.The clinical features of DN are albuminuria, progressive renal dysfunction,hypertension, edema, and severe renal failure in the late stages. It can be reversed the diabetic nephropathy In early stage under the right treatment.But once patients increased the urinary albumin excretion rate, the disease will be progressively, and following proteinuria, edema and so on, until the end stage renal failure in uremia. Therefore, the key to treat DN is early-diagnosis and prevention diabetic nephropathy. Up till now, evidence-based medicine proves the effective treatment of diabetic nephropathy mainly through hypoglycemic, antihypertensive, regulating lipid, anticoagulation, limiting protein intake, and other Western symptomatic treatment. But there are still have some limitations. It is difficult to change the DN process fundamentally.So how to treat and prevent the DN effectively have become issues of common concern all over the world. Chinese medicine treatment of DN have effect on improving clinical symptoms, reduce the biochemical indicators, and to protect the kidneys. Therefore Chinese medicine prevention and treatment of diabetic nephropathy have huge potential and prospects. It is clinical and scientific important to do some research prevention or delay the occurrence of DN.Objective To observe with decoction of Chinese medicine Jiangtang baoshen No.l recipe in treatment of diabetic nephropathy (Ⅲ stage) with qiyin deficiency with blood stasis syndrome in patients with clinical efficacy.Methods 60 cases of the patients, were randomly divided into treatment group and control group,30 cases in each group, were given ARB. The treatment group was given Jiangtang baoshen No.1 recipe. After 2 courses of treatment, observe the changes of TCM syndrome score,cystatin C(Cys-C),fasting blood glucose(FBG),blood lipids(TC、HDL-C、LDL-C、TG), 24 hour urinary protein quantitation in two groups before and after treatment. And monitoring of blood routine, urine routine, stool routine and liver and kidney function,electrocardiogram and other safety indicators, statistical analysis of the results, and evaluate the clinical efficacy and safety of the prescription.Results Jiangtang baoshen No.1 recipe can effectively improve the clinicalsymptomsin patients with diabetic nephropathy, improve lipid metabolism disorders, decrease Cys-C levels,ruduce the excretion of urine protein.There were no significant changes in the two groups before and after treatment the safety index, have good safety.Conclusion Jiangtang baoshen No.1 recipe on type 2 diabetic nephropathy (Ⅲ stage)with qiyin deficiency with blood stasis syndrome has a significant clinical efficacy in treatment of patients, and high safety, has positive significance for prevention and delay the development of DN.