The Study Of Cervical HPV Infection During Late Pregnancy And Influencing Factors

Objective Taking cervical shedding cells HPV test in order to know the HPV infection and genotype during late pregnancy and after puerperium, study the relationship of the age,gestational diabetes, the delivery times, living environment and HPV infection during pregnancy, in order to provides theory basis that take the HPV testing in pregnancy inspection regular testing project and take the HPV testing during pregnancy in the future.Methods From April 2014 to October 2014, randomly selected 223 volunteers age of 21 to 45 during late pregnant to take HPV test who would given birth to in the Third Affiliated Hospital of Jinan University Zhuhai People’s Hospital, recorded their clinical datas and informations, collected their cervical shedding cells, informed them back for review to collect their cervical shedding cells after puerperium again. Gathered specimens, HPV infection and genetic subtypes were analyzed by GP PCR-SBT and NCBI BLAST. Used the SPSS 13.0(PASW Statistics,IBM,USA)to analyse the HPV infection and the affecting factors of HPV infection during pregnancy.Results A total of 30 cases of 181 satisfactory research object were detected positive during late pregnancy, with the positive rate of 16.57%(30/181), only 12 cases were detected positive for review after puerperium in 24 cases of positive HPV during late pregnancy, the natural reversal rate is 50.0%; A total of 10 cases(41.67%, 10/24)of high risk HPV(HR-HPV)during late pregnancy, in the order the genotype distribution is HPV-18(16.67%, 4/24),-31(8.33%,2/24);-16(4.17%, 1/24),-39(4.17%, 1/24),-52(4.17%, 1/24),-58(4.17%, 1/24);A total of 14 cases(58.33%, 14/24)of low risk HPV(LR-HPV), in the order the genotype distribution is HPV-62(29.17%, 7/24),-53 (16.67%, 4/24),-42(8.33%, 2/24),-11(4.17%, 1/24). The proportion of all ages,age≤25 years old(4.5%, 1/22), 26 ~ 30 years old(13.4%, 13/97), 31 ~ 35 years old(26.5%, 13/49), >35 years(23.1%, 3/13); Gestational diabetes( 23.8%, 5/21), not gestational diabetes(15.6%, 25/160);The first time delivery(17.1%, 21/123), not the first time delivery(15.5%, 9/58);Living city in the first 10 years(18.7%, 26/139), living suburb in the first 10 years(9.5%, 4/42). All statistical group of the age, gestational diabetes, the delivery times, living environment, P>0.05, the difference is not statistically significant.Conclusion The cervical HPV positive rate is almost the same with other reports during late pregnancy, the natural reversal rate is 50.0% after puerperium, the genotype is different from other reports with its own regional characteristic, HPV infection during pregnancy didn’t found obvious relation with the age, gestational diabetes, production times, the living environment. It is safe to take the HPV testing during late pregnancy. In order to reduce the incidence of cervical cancer during pregnancy we suggest that take the HPV testing in pregnancy inspection regular testing project and take the HPV testing during pregnancy.