Correlation Study Of Testosterone, Estradiol Levels And Serum Uric Acid In Hui And Han Middle-aged Population From Urban Community In Ning Xia Hui Autonomous Region

Objective 1. To investigate prevalence of hyperuricemia in middle-aged Hui and Han populations in urban community of Ning Xia Hui Autonomous Region. 2. Analysis the correlation between the levels of blood uric acid and testosterone, estradiol in these populations. 3. To investigate the risk factors of hyperuricemia in middle-aged Hui and Han populations in urban community of Ning Xia.Method: We recruited 1295 inhabitants from five urban communities in Yinchuan and Wuzhong cities. The survey and the physical examination were carried out from August 2011 to December 2012. The uric acid(UA), testosterone(T), estradiol(E2), fast insulin(INS), sex hormone binding globulin(SHBG), total cholesterol(TC), triglyceride(TG), fasting blood glucose(FBG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol( LDL-C) and some other blood biochemical indexes were tested. The SPSS17.0 software was used for data analysis.Results: 1.Testosterone in males was decreasing after the age 65(F=7.146, P=0.000), estradiol in females was decreasing after the age 55(F=5.315, P=0.001).2. In this study, the prevalence rate of hyperuricemia was 7.87% in Hui nationality; and the prevalence rate of hyperuricemia was 12.47% in Han nationality. The prevalence rate of hyperuricemia was significant different between Hui and Han nationalities(2x=6.385, P = 0.011).3. The prevalence rate of hyperuricemia was 17.82% in males; and the prevalence rate was 4.39% in females. The prevalence rate of hyperuricemia was significantly higher in males than it’s in females(2x=59.839,P = 0.000), also in each age group respectively(P <0.05).4. The prevalence rate of hyperuricemia was significantly higher in hypertension group than it’s in non-hypertension group both in Hui and Han(P<0.05).5. In statistic analysis with multi-factor linear regression model, blood uric acid level was increasing with testosterone(B=0.037,P=0.000), fasting blood glucose(B=2.475, P=0.011), triglyceride(B=10.066, P=0.000), systolic pressure(B=0.379, P=0.001), and was decreasing with high density lipoprotein cholesterol(B=-8.706, P=0.000). Conclusions: 1. The prevalence rate of hyperuricemia is significantly different in Hui and Han two ethnic populations and genders.2. The blood uric acid is related to hypertension, fast blood glucose and lipid levels.3. It shows negative correlation between high density lipoprotein cholesterol and blood uric acid levels.4. Testosterone level is relatd to blood uric acid positively. The hyperuricemia is related to gender, hypertension, systolic blood pressure and the levels of triglyceride. This study provides the evidence that to control blood pressure and lipid levels in normal level could prevent hyperuricemia. This study provides the evidence that prevalence of hyperuricemia is associated with gender and blood pressure, and to control blood pressure and lipid levels in normal level could prevent hyperuricemia.