The Correlation Between Glycosylated Hemoglobin And The Severity Of Coronary Artery Disease And Cardiac Function

ObjectiveTo investigate whether the different levels of HbAlc will affect the severity of coronary artery disease and cardiac function of coronary heart disease. The aim of the study is to explore the clinical value of HbAlc for coronary heart disease patients.MethodA total of 150 chest pain patients were selected from the Department of Cardiology of the Second Affiliated Hospital of Zhengzhou University. There were 81 males (54%) and 69 females (46%), the average age of them was (57.1±10.7) years old. All patients were measured in the following indicators:TC, TG, HDL-C, LDL-C, FPG, HbAlc from venous blood and LVDd, LVEF form echocardiography. Coronary angiography (CAG) was performed on all patients.According to the HbAlc levels, the patients were categorized into 3 groups: Normal Group(HbAlc≤5.6%, n=45), Critical Group(HbAlc,5.7%～6.4%, n=48), High Level Group(HbAlc≥6.5%, n=57). Compare the clinical data, degree of severity of coronary artery, LVDd and LVEF value among different groups.According to the degree of severity of coronary artery disease, the patients were categorized into 4 groups:Group without coronary lesion (no substantial stenosis, n=30), Group with single vessel disease (n=43), Group with double-vessel disease (n=45), Group with triple-vessel disease (n=32). Compare the differences to HbAlc levels among 4 groups.Results1.Normal Group, Critical Group, and High Level Group show insignificant statistical differences in terms of age, gender composition, smoking, hypertension and history of diabetes. FPG and HDL-C of different groups show significant differences (P<0.05). FPG increases, whereas HDL-C decreases among 3 groups.2. Defining High Risk Group and High Level Group as abnormal, the results show that 105 samples have abnormal HbAlc level out of the total 150 samples, about 70%. The severity of coronary artery disease was correlated with HbAlc levels (r=0.285, P<0.05). HbAlc level in groups with coronary lesion of single vessel disease, double-vessel disease and triple-vessel disease were significantly higher than the group without coronary lesion. While the HbAlc level in double-vessel disease and triple-vessel disease group were higher than single vessel disease group, triple-vessel disease group was higher than double-vessel disease group. There were statistical significance among 4 groups (P<0.05).3. There was a rank correlation between HbAlc level and LVDd、LVEF (r=0.198, r=-0.190, P<0.05). With the different HbAlc level increasing, the LVDd enlarges, and LVEF decreases. The LVDd was linear correlated with LVEF(r=-0.850, P<0.01), the Logistic regression equation is LVEF=124.929-1.422×LVDd. There were statistical significance among 3 groups (P<0.05).Conclusions1.Abnormal HbAlc level is one of the major risk factors of occurring and developing with coronary heart disease.2.There is a positive correlation between HbAlc level and degree of severity of coronary lesion. With the HbAlc level going up, the severity of coronary will aggravate.3.There is a rank correlation between HbAlc level and LVDd、LVEF.The higher the HbAlc level, LVDd is greater, while the LVEF is lower.