The Relationship Between Leukoaraiosis And Cognitive Impairment

Objective:Cerebral white matter osteoporosis(leukoaraiosis, LA) is a type of brain small vascular lesions.In recent years, the relationship between LA and cognitive dysfunction has been more and more attention by many scholars both at home and abroad.By cranial MRI in patients with multiple model checking, this study combined with Fazakas scale, simple intelligent state examination(MMSE) Montreal cognitive function scale(MOCA) and event related potential P300 understanding degree of different regions, different correlation of LA and cognitive dysfunction, further explorepossible risk factor for cognitive dysfunction in LA.On the basis of early detection and intervention in LA from mild cognitive impairment to dementia in patients with delay is of great clinical significance.Materials and Methods :cases of normal control group(14 cases of male, female 16 cases, mean age 69.57±7.49 years), record the subjects’ personal history, past medical history, family history, and risk factors of cerebrovascular diseases related to conventional basic information.This research first line head mri in patients with LA routine inspection, including T1(T1WI), T2 weighted t2-weighted scans(T2WI and FLAIR sequences, use Fazakas scale will be 80 cases of patients with LA lesion severity was divided into three groups, namely the mild LA34 example, moderate LA20 example, severe LA26 cases;, according to the part of the white matter lesions involving the LA group is divided into near room weeks narrator mass lesions(periventricularlesions, PVL) 41 cases and deep white matter lesions(deep white matter lesions, DWML) 39 cases.Combined with MMSE, MOCA scale and analysis of event related potential P300 LA the influence of different degree of known function, and analyzes different part, LA and MOCA scale the correlation of different cognitive domains.Combining MMES scale and MOCA scale LA patients divided into cognitive dysfunction group(60 cases, mean age 68.46± 4.35 years) and cognitive function in normal group(20 people, average age 65.53±5.19 years), the two groups all patients for age, smoking history, drinking history, education, age, hypertension, hyperlipidemia,diabetes, coronary heart disease(CHD), comparing the related basic data analysis and LA for cognitive decline in cognitive function may be risk factors.All data analysis using SPSS19.0 statistical software package, measurement data using mean plus or minus said, between group differences comparing with independent samples t test,comparison between count data set by chi-square test, more than mean comparison using single factor analysis of variance between groups, two two compared the SNK- q test.Using multiariable Logistic regression model, calculate the odds ratio(OR) factors,analyze the related risk factors for LA.P < 0.05 was statistically significant.Results:1. Patients with mild LA in addition to the language ability, other visual space and execution ability, naming, attention, abstract, delayed recall and there was no statistically difference orientation force and the control group(P > 0.05), and moderate LA lesion group and the control group to compare, visual space and execution, attention,language and delayed recall, directional force difference has statistics meaning(P <0.05);When severe group in space and execution, naming, attention, language ability,delayed recall, directional force scores were significantly lower(P < 0. 05), prompt severe LA lesions influence to almost all of the cognitive domain.LA different level set of MMSE and MOCA score lower than the control group, the overall scores on cognitive function, statistically significant difference(P < 0.05), and, in the restructuring and contrast more obvious difference(P < 0.05).2. Mild LAP300 amplitude no statistical differences compared with control group(P >0.05), and the restructuring of LA P300 amplitude difference compared with control group(P < 0.01), different levels of LA groups of P300 latency period compared with the control group was statistically difference(P < 0.01)3. DWML group in Mo CA scores, visual space and executive function, language features, attention to score lower than the control group(P < 0.05);PVL group in Mo CA scores, visual space and executive function, naming, language features, delayed recall,attention to score lower than the control group(P < 0.05);PVL group in naming,language features, the delayed recall score below DWML group(P < 0.05);DWML visual space and executive function below the PVL group(P < 0.05).4. Cognitive dysfunction in patients with LA group compared with normal group of statistical analysis, age, hypertension, diabetes, hyperlipidemia, statistically significant differences statistically significant(P < o. 05), gender, smoking, drinking, and fixed number of year of the education, coronary heart disease(CHD), homocysteine levels,allergic CRP has no statistical significance(P > 0.05).The above have statistically significant risk factors related to Logistic multifactor regression analysis found that age,hypertension, diabetes, are caused in LA independent risk factors of cognitive dysfunction.Conclusions:1.LA was positively associated with the degree of level and cognitive function obstacle.2.P300 is clinical early diagnosis of cognitive dysfunction in patients with LA objective and sensitive indicator.3.LA area is different, can cause different cognitive impairment of cognitive domain.4.Age, hypertension, diabetes, hyperlipidemia is the cause of LA resulting in a decline in cognitive function in patients with risk factors, including age, hypertension, diabetes to LA independent risk factors for the development of cognitive function decline.