Research On The TCM Syndromes And Treatment Regularity Of Active Ulcerative Colitis

Objective:To study the distribution of age, sex, onset season, course of disease, clinical types, severity of the disease, clinical symptoms, lesions range, colonoscopy findings in various traditional Chinese medicine (TCM) syndromes of ulcerative colitis (UC). To summarize the distribution of TCM syndromes and study different treatment methods of the disease, in order to provide further clinical evidence of the establishment and improvement of TCM treatment programs in ulcerative colitis patients.Methods:The data of UC inpatients of teaching Hospital of Chengdu University of TCM in recent3years were collected and summarized according to clinical questionnaire designed before, in order to discuss the distribution regularity of TCM syndromes and the rules of the treatment in UC patients.Results:1.99UC patients were collected in this research. The proportion of male and female was1:1.06, and the average age was45.95±14.50years old.2. The large intestine dampness-heat syndrome was the most common syndrome in the youth group, while the spleen qi deficiency syndrome was the most common syndrome in the adult group. The mixed cold and heat syndrome was the most common syndrome in the old group.3. The large intestine dampness-heat syndrome was the dominant syndrome in male patients, while the liver depression and spleen qi deficiency syndrome was the dominant syndrome in female patients.4. The onset season was sorted as followed:summer>spring>winter>autumn.5. Lesions range of UC mainly affected the left colon.6. Chronic relapsing was the popular clinical type. 7. The mild cases were the most common type among all the cases, while the large intestine damp-heat syndrome was the common type in the mild cases, and the spleen qi deficiency syndrome was the common type in the middle cases, and the large intestine damp-heat syndrome was the common type in the severity cases.8. The course was sorted as followed:less than5years>5to10years> more than10years. The large intestine damp-heat syndrome was the common type in patients whose course was less than5years, while the spleen qi deficiency syndrome was the common type in patients whose course was5～10years, and the liver-stagnation and spleen-deficiency syndrome was the common type in patients whose course was over10years. The mild ones were the most common case in patients whose course were less than5years, and the middle and severity ones were the most common case in patients whose course were5～10years and longer than10years.9. The common symptoms were abdominal pain, diarrhea, mucus and pus. Most cases did not have extra-intestinal manifestations.10. Endoscopic mucosal manifestations mainly included edema, erosion and ulceration. colonoscopy histological classification of class Ⅱ as the main.11. There was a significant difference between TCM syndromes and age, histological rank. There was no significant difference between TCM syndromes and duration, extent of disease, severity of disease, clinical types, hemoglobin, albumin, common symptoms, colonoscopy mucosal manifestations, the onset of the season, psyche.Conclusion:1. The large intestine damp-heat syndrome and the spleen-deficiency syndrome were the most common TCM syndrome.2.25to40years and55to70years old were the peak incidence of the disease. We can add drugs which can resolve bowel dampness to treat the youth group of patients with ulcerative colitis on the basis of the dialectic, and drugs which can benefit spleen qi to treat the adult and the old group of patients with ulcerative colitis.3. There was no significant difference between the incidence of male and female patients. Drugs which can resolve bowel dampness could be used while treating male patients with ulcerative colitis; and drugs which can benefit spleen and regulate liver drugs could be used while treating female patients with ulcerative colitis.4. Drugs which can benefit spleen could be used while treating patients with Endoscopic classification Class I; and drugs which can resolve dampness could be used while treating patients with Endoscopic classification Class Ⅱ>Ⅲ.