Determination Of Serum Omentin And Sfrp-5Levels And Evaluation The Significance In Obstructive Sleep Apnea Hypopnea Syndrome Patients

Obstructive apnea-hypopnea syndrome (OSAHS) is caused by apartial or complete upper airway obstruction in the process of sleep atnight, with recurrent hypoxemia and (or) apnea. The main characters aresnoring at night, daytime sleepiness, concentrating distraction,accompanied by a series of multiple system dysfunction. The OSAHS iseasy to cause complications such as high blood pressure, diabetes,cardiovascular, cerebrovascular diseases, which lead to serious impact onpatients＇ quality of life and their lifetime. OSAHS pathogenesis iscomplex and affected by various factors including age, sex, obesity,endocrine disorders, genetic factors, et al. Hypoxia can cause abnormalexpression of adipokine in OSAHS patients. Omentin and secretedfrizzled-related protein-5are the new discovered adipokines.Omentin is a novel discovered adipokine in2003which actedspecific expression by the omental adipose tissue. Omentin is highexpressed in human placental, ovarian and low expressed in the smallintestine, lungs and heart. Omentin can be detected only in muscle andkidney, while in other organizations could not be detected at all. Currently,many studies have found Omentin takes part in the metabolism of obesity,diabetes and cardiovascular disease widely and involved in the regulationof glucose lipid metabolic balance and vascular endothelial function.Therefore, the Omentin may have involved in the pathogenesis of OSAHS,but there is no final conclusion. Sfrp-5is a novel adipokine, a member ofsecreted frizzled-related protein (Secreted frizzled-related protein, Sfrp) family. Sfrp-5gene located on chromosome10q24.1and contains threeexons, in the retinal pigment epithelium cells highly expressed, alsoexpressed in the pancreas. Previous studies on Sfrp-5is mainly embryonicdevelopment, apoptosis and tumor areas. Recently, many studies haveshown Sfrp-5may be associated with obesity and impaired glucosetolerance. Currently there is no related research reports about therelationship between Sfrp-5with OSAHS.The aim of this study is to investigate serum Omentin and Sfrp-5concentration, low-oxygen index(AHI), body mass index (BMI), HIF-1αand other indicators in OSAHS patients to explore the role of Omentin andSfrp-5in the pathogenesis of OSAHS.In respiratory sleep monitoring laboratory of Peking union medicalcollege hospital, we selected80male patients as the subjects. All thesubjects underwent more than7hours Polysonmography(PSG) in all nightsleep. And, we measured clinical related indicators(neck circumference,waist, hip circumference, BMI), serum about indicators (fasting bloodglucose, lipid, high-sensitivity C-reactive protein) and PSG monitoring(brain electric, eye moving, muscle electric, mouth nasal breathing, chestabdominal type breathing, posture, ECG and the by skin blood oxygensaturated degrees, et al). We also detected the serum Omentin and Sfrp-5concentration by using enzyme-linked immunosorbent assay (ELISA).The results showed that serum Omentin levels were significantlydecreased in overweight OSAHS patients compared with overweight non-OSAHS patients(P<0.05), which suggested Omentin may play animportant role in the development of OSAHS. Serum concentration ofOmentin in OSAHS patients was not related to BMI, waist circumferenceand AHI, but was related to HDL-C and adiponectin positively (P<0.05).Serum Sfrp-5levels is a rising trend in overweigh OSAHS group, withoutstatistical significance (P>0.05). There was no correlation between theSfrp-5concentration and BMI, WC, AHI (P>0.05) in overweight OSAHS, but there was negative correlation with HDL-C and MSaO2(P<0.05); andalso hs-CRP, SLT90%, HIF-1α were positively related (P<0.05). However,there were not distinct relevant in the concentration of serum Omentin andBMI, waist circumference, hs-CRP in OSAHS patients. In overweightOSAHS group the percentage of shallow sleep time is significantly higherthan overweight non-OSAHS group and control group (P<0.01), and thepercentage of deep sleep time is significantly lower than overweightnon-OSAHS group and control group (P<0.01). The above results showedthat the OSAHS patients existed disorders of nocturnal sleep architecture.In conclusion, serum Omentin levels were decreased, Sfrp-5levelshad related with MSaO2and SLT90%in overweight OSAHS patientswhich suggested Omentin, Sfrp-5may be involved in the occurrence anddevelopment of OSAHS.