The Changes And Implications Of Serum Omentin, Irisin Levels In Patients With Obstructive Sleep Apnea Hypopnea Syndrome

Objective:To investigate the changes of serum Omentin, Irisin levels in patients with Obstructive sleep apnea-hypopnea syndrome (OSAHS).Method:A total of 130 patients from the patients ongoing of sleep apnea in the sleep disorder center in ZhongDa Hospital from November 2013 to November 2014 were recruited and underwent polysomnography. Exclusive criterias are hypertension, diabetes, hyperlipoidemia and cardiovascular diseases. These patients are divided into 12 differents groups according to AHI and BMI. Serum Omentin and Irisin levels are tested by using the method of enzyme-linked immunoassay.Results:1. Omentin:1.1 Excluding the influence of age and gender, Omentin levels of serve OSAHS objects are lower than objects with no, mild, middle OSAHS in each BMI-matching group (p< 0.05). Omentin levels of middle OSAHS objects are lower than objects with no, mild OSAHS (p< 0.05). There are no statictical differences between Omentin levels of mild and no OSAHS objects (p> 0.05).1.2 Excluding the influence of age and gender, Omentin levels of obesity objects are lower than objects of normal weight in each AHI-matching group (p< 0.05). In mild, middle and serve groups, Omentin levels of obesity objects are lower than objects who are overweight (p< 0.05). In no OSAHS group. There are no statictical differences between Omentin levels of overweight and obesity objects (p> 0.05). In no, mild, serve OSAHS groups, Omentin levels of overweight objects are lower than objects of normal weight (p< 0.05). There are no statictical differences between Omentin levels of overweight and normalweight objects in middle OSAHS group (p> 0.05).1.3 In OSAHS groups, Omentin levels show negative correlations with AHI, BMI, neck circumference, waist-to-hip ratio and percent of body fat. Omentin levels show positive correlations with MsaO2 and LSaO2.1.4 In no OSAHS groups, Omentin levels show negative correlations with neck circumference, waist-to-hip ratio and percent of body fat.2. Irisin2.1 Excluding the influence of age and gender, Irisin levels of serve OSAHS objects are lower than objects with no, mild, middle OSAHS in each BMI-matching group (p< 0.05). Irisin levels of middle OSAHS objects are lower than objects with no, mild OSAHS (p< 0.05). In normal weight groups, Irisin levels of mild OSAHS objects are lower than objects with no OSAHS and there are no statictical differences between Irisin levels of overweight and obesity objects (p> 0.05).2.2 Excluding the influence of age and gender, Irisin levels of obesity objects are lower than objects of normal weight and overweight in each AHI-matching group (p< 0.05). In no, mild and serve OSAHS groups, Irisin levels of obesity objects are lower than objects of overweight (p< 0.05). In middle OSAHS groups, there are no statictical differences between Irisin levels of overweight and obesity objects (p> 0.05).2.3 In OSAHS groups, Irisin levels show negative correlations with AHI, BMI, neck circumference, waist-to-hip ratio and percent of body fat. Irisin levels show positive correlations with MsaO2 and LSaO2.2.4 In no OSAHS groups, Irisin levels show negative correlations with neck circumference, waist-to-hip ratio and percent of body fat.Conclusion:For the subjects who are diagnosed as OSAHS, serum Omentin, Irisin levels are negatively associated with AHI. For all the subject, serum Omentin, Irisin levels are negatively associated with BMI.