Effects Of Obesity On Sleep Apnea Disorder And Nocturnal Hypoxia In Patients With Obstructive Sleep Apnea-hypopnea Syndrome

Objective:Obesity,as an important risk factor of obstructive sleep apnea hypopnea syndrome（OSAHS）,plays an important role in the pathogenesis and prognosis of OSAHS.The purpose of this study was to compare the sleep apnea hypopnea index（AHI）,Mean oxygen saturation（MSa O₂）,Lowest oxygen saturation（LSa O₂）and the percentage of time spent with Sa O₂ below 90%(SIT₉₀)in patients with OSAHS among groups with different body mass indexes and to explore the effect of obesity on patients with OSAHS.Methods:1152 subjects were diagnosed as OSAHS by polysomnography（PSG）in Handan Central Hospital from 2016 to 2020.including 948 males（82.3%）and 204females（17.7%）.According to BMI,they were divided into three groups:119 cases in Normal group（10.3%）,418 cases（36.3%）in overweight group,and 615cases（53.4%）in obesity group.The parameters of AHI,MSa O2,LSa O₂and SIT₉₀were recorded and compared.Results:There were significant differences in AHI and hypoxia indicators in OSAHS patients among different BMI groups（p<0.001）.Spearman correlation analysis showed that the correlation coefficients among BMI and AHI,MSa O₂,LSa O₂,and SIT₉₀ were 0.444,-0.451,-0.392,and 0.420（P<0.05）,respectively,and the correlation coefficients of AHI with MSa O₂,LSa O₂,and SIT₉₀ were-0.731,-0.674,0.751（P<0.05）;On the whole,AHI will increased 4.88%when BMI added 1kg/m²,logistic regression analysis showed the risk of patients suffering from moderate to severe OSAHS increased 21.3%by 1kg/m² added in BMI,The cut-off value of BMI for diagnosis moderate to severe OSAHS was 27.8kg/m²,and the sensitivity and specificity were62.85%and 69.79%,respectively.Conclusion:Obesity is related to the degree of sleep disordered breathing and hypoxia in OSAHS patients,sleep-disordered breathing index and the degree of hypoxia aggravated with the increase of BMI.