Expression Of TrkA In Uterine Iunctional Zone And The Relationship With Dysmenorrhea In Patients With Adenomyosis

Objective:To investigate the expression of TrkA in the uterine junctional zone(JZ), and evaluate its relationship with the degree of dysmenorrhea and secrum CA125levels in patients with adenomyosis(AM).Methods:Samples of JZ were collected from twenty-four adenomyosis patients(15patients in proliferative phase and9patients in secretory phase) and fifteen uterine fibroids patients(12patients in proliferative phase and3patients in secretory phase), employed Immunohistochemical streptavidin-biotin peroxidase (SP) method to detect the expression of TrkA in the uterine junctional zone. Use visual analogue scales(visual analogue scale/score, VAS) to make the dysmenorrhea score of adenomyosis.Results:1. TrkA was expressed in both the endometrium and JZ.2. Expression of TrkA in both endometrial and JZ of AM group was stronger than control group(P<0.05). Expression of TrkA in JZ of both AM and control group was stronger than endometrial group(P<0.05). 3. Expression of TrkA in proliferative phase was stronger compared with secretory phase in two groups of JZ(P<0.05).4. There was significant correlation between the expression TrkA in JZ of AM group and the degree of dysmenorrhea in patients with adenomyosis (r=0.347, P<0.05).5. There was significant correlation between the expression TrkA in JZ of AM group and the the serum CA125levels (r=0.678, P<0.05).Conclusion:Expression of TrkA increases in AM, having a relationship of dysmenorrhea. It suggests TrkA is associated with dysmenorrhea in the AM.