The Study Of The Tpye Of Denficiency Both Of Lung And Spleen Of Interstitial Pneumonia In Law Of Syndrome And Treatment And Series Hebal Medicine

Through clinical case studies and animal studies combine to explore integrativestandard treatment program of IP of type lung and spleen deficiency.Part of clinical trials toclinical cases for the study，conducted clinical drug experiment and track the course oftreatment， and finally the use of statistical methods for statistical analysis，to observe theadvantages of integrative medicine of IP of type lung and spleen deficiency.Animalexperiment，through the construction of IP of type lung and spleen deficiency，fromimmune，vascular remodeling，antioxidant mechanisms to explore different aspects of theefficacy of TCM therapy for IP.Part of the clinical trial，select meets the inclusion criteria of IP lung and spleendeficiency type90patients signed an informed consent form. Part of the clinical trial，select meets the inclusion criteria IP deficiency of both lung and spleen type90patientssigned informed consent. The90patients were randomly divided into3groups，namedWestern medicine treatment group， unilateral Integrative Medicine Integrative therapygroup and the treatment group in compound.Respectively given western medicine，western medicine and traditional Chinese medicine DaLuoyin， western medicine andtraditional Chinese medicine PeiTuYiJinFang1month of treatment， follow-upsurvey.After treatment， statistical case data， fill in the efficacy scale based on clinicalcriteria， using statistical methods to analyze， draw conclusions.Experimental animals selected SPF SD male rats were randomly divided into group A（control group）， group B（model group）， group C（TCM treatment group）， groupD（Hormone therapy group）， group E（TCM plus hormone therapy group）5groups， each group had8rats.By intratracheal injection Bleomycin and FanXieYe gavage toestablish rats model of IP of Type lung and spleen deficiency.After create the models，respectively given them normal feed，hormone，TCM，hormone and TCM treatment for14days.Collect abdominal aortic blood and lung tissue to observe the general situation. Underthe microscope to observe pathological changes and ultrastructure of lung tissue.RT-PCRto detect the expression of VEGF in lung tissue，immunohistochemistry was used to detectthe expression of PDGF and Nrf-2’s in lung tissue，ELISA to detect the expression ofTGF-β1、TNF-α、IL-8and abdominal aortic blood IgG in lung tissue，Chemiluminescenceassay abdominal aortic blood SOD， GSH synthesis case.After data analysis to observeIntegrative Medicine the advantages of IP.Clinical studies have shown that the IP patients of type lung and spleen deficiencywith western medicine and TCM after the PeiTuYiJinFang treatment is better than theother two groups.The results showed that clinically in the treatment of IP of type lung andspleen deficiency，while the use of steroids， anti-fibrosis drug， with the benefit lung andspleen， phlegm meridians， stasis of traditional Chinese medicine， can play a goodrole.Animal studies show that the disease process in IP of type lung and spleen deficiency，accelerate vascular remodeling，immune function，antioxidant and inflammatory changesincrease the skills diminished and many other phenomena exist.After treatment， theimprovement in the combination therapy group was significantly better than the hormonetherapy group and the treatment group， lesions from multiple perspectives reveal themechanism of IP of type lung and spleen deficiency.The result confirmed that integrativemedicine can improve the immune function，antioxidant function，inflammatory changes，vascular remodeling of rat model.All of them provide the basis and ideas for theapplication of PeiTuYiJin method.