The Morphological Changes Of Langerhans Cells In Condyloma Acuminata

Background：Condyloma acuminatum is a sexually transmitted disease, is caused byhuman papilloma virus (HPV) infection. In recent years, its incidence is increasing year byyear, has become one of the most common sexually transmitted diseases. The infectivity isstrong, the recurrence rate is high and it has become a difficult problem in clinical treatment.This HPV into the human body is the persistent infection and immune surveillance function ofbody disorders related to. Langerhans cells (Langerhans cells LC) is the epidermis powerfulantigen presenting cells and play an important role in immune surveillance. HPV can reduceCA lesions of immune surveillance function by reducing the local LC numberObjective： by immunohistochemistry (SP method) were observed, the number ofLangerhans cells in30cases of condyloma acuminatum tissues and15cases of normal tissuesdistribution and morphology under light microscope.Methods： immunohistochemistry was used to detect the CA lesions in30patients withCA and15cases of normal prepuce tissues of Lcs surface markers of CD-la and S-100positive expression of CD-1a and S-100, were counted under light microscope and observetheir morphology and distribution, finally carries on the statistical analysis；Results：1, normal skin tissues CD-1a immunohistochemical positive cells scattered in theepidermal basal layer, prickle cell layer, form a few were round, polygonal, with longprocesses. CA in the epidermis of CDla+LCs distributed mainly in the basal layer, irregularshape, cell body shrinkage, no cytoplasmic processes. The number of CDla+LC2, CA inlesions was (44.49+36.40), control group CDla+LC (140.26+19.15) number. The number ofCA lesions group and control group CDla+LC in the epidermis, there was significantdifference between two groups (P<0.05). Typical dendritic cells occurred in3, normal skin,LC were round, oval or punctate, short and small cell processes, or even disappear. Individualspecimens of the epidermal part S100+LC disappeared. The number of normal skin tissuegroup S100+LC was (72.58+26.32)/high power field, no typical dendritic cells in CAlesions, visible only very few showed punctate cytoplasmic processes of structure, expressionof some specimens without S100+LC. The number of individual specimens of epidermal S100+LC S a local disappearance of100+LC4, CA in lesional epidermis was (15.37+18.84), the number of S control group100+LC normal skin epidermis was (72.58+26.32), the numberof S100+LC CA lesions and normal skin epidermis in group, compared two groups ofdifference there was a significant correlation (P<0.05).Conclusion： CA LC significantly reduced the number of lesions, and too much LCshowed morphological change, these changes may suggest that CA in the lesions of LCpresents the damaged state...