The Relationship Between Peripheral Blood T Cells Subpopulation And Partial Cell-mediated Immunity In Patients With Condyloma Acuminatum

Objective: To study the changes of T cell subpopulation (CD4+,CD8+) in both peripheral blood and partial lesions in patients with condyloma acuminatum(CA),and the relationship. Methods: To describe the levels of CD4+T cell,CD8+T cell and CD4+/CD8+ in 42 patients with CA and 30 normal controls by flow cytometry;to count the numbers of T cell subpopulation in partial lesions with CA. Results: The levels of CD4+ T cell ,CD4+/CD8+ T cell in peripheral blood of the CA were lower than those of the controls(P<0.01).The level of CD8+ T cell was higher than that of the controls(P<0.01). And the levels of CD4+ T cell ,CD8+ T cell in partial lesions of the CA were higher than those of the controls(P<0.01).The level of CD4+/CD8+ T cell in partial lesions of the CA was lower than that of the controls(P<0.01). The change of peripheral T cell subpopulation was not related to partial lesions T cell subpopulation in patients with CA. Conclusions: The cell-mediated immunodeficiency exists in patients with CA.The occurrence of CA(including subclinic infection,latent infection),recrudescence and reinfection were associated with the cell-mediated immunity,which provided the guide for the therapy of CA.