Research The Relation Of PCOS And Hypothyroidism And The Distribution Of Traditional Chinese Medicine Syndromes

Objective:The paper aims to study the thyroid function, female endocrine, glycolipidmetabolism and the distribution of TCM syndromes about patients with polycystic ovariansyndrome, at the same time, and to investigate the relationship between polycystic ovariansyndrome and hypothyroidism.Methods:The131PCOS patients are defined as the object of observation to examineserum follicle-stimulating hormone(FSH), luteinizing hormone(LH), testosterone(T),estradiol(E2), prolactin(PRL), thyrotropic hormone(TSH), free thyroxine(FT4), freetriiodothyronine(FT3), low density lipoprotein(LDL-L), high-density lipoprotein(HDL-L),triglyceride(TG), cholesterol(TC), glucose (GLU) and insulin(INS). According to the levelof FT3, FT4and TSH, the patients are divided into hypothyroidism group(39cases),euthyroidism group(89cases) and hyperthyroidism group (3cases) to analyze in statisticalway.Results:(1)There are39(29.77%) patients with hypothyroidism,3(2.29%) patientswith hyperthyroidism,89(67.94%) patients with normal thyroid function in131PCOSpatients.Because the number of cases is less in hyperthyroidism group, which is removed.(2)Two groups show significant difference in BMI (P<0.01), and no marked difference inacne, hairy and acanthosis nigricans (P>0.05).(3)There are not significant difference inblood E2, FSH, LH, LH/FSH, T and PRL value between the two groups(P>0.05).(4)Twogroups show difference in blood INS, Homa-IR, TG, TC and LDL-C value (P<0.05),andno marked difference in blood GLU and HDL-C value (P>0.05).(5)The linear regressionanalysis shows that TSH has a positive correlation with Homa-IR and INS in the PCOSpatients(P<0.01), and no relevance with serum T, E2, FSH, LH, LH/FSH, PRL,GLU, TG, TC, HDL-C and LDL-C level(P>0.05).(6)Patients with delayed menorrhea have29cases,the amenorrhea have5cases and the uterine bleeding have5cases in hypothyroidismgroup. Patients with delayed menorrhea have72cases, the amenorrhea have13cases andthe uterine bleeding have4cases in euthyroidism group.(7)The frequency of TCMsymptoms ranks from high to low as follows:soreness and weakness of waist and knees,extreme chilliness and leucorrhea less so on in hypothyroidism group.The normal group issoreness and weakness of waist and knees, leucorrhea less and menstrual color dark withblood clots so on. Patients with PCOS are based on pink tongue, white fur, thin pulse.(8)The frequency of TCM syndromes ranks from high to low as follows:kidney yangdeficiency(28.21%), kidney deficiency and blood stasis(23.08%), kidney qideficiency(17.95%), spleen vacuity with phlegm-damp(17.95%) and liver-qiinvasion(5.13%) so on in hypothyroidism group. The normal group is kidney qideficiency(28.09%), kidney deficiency and blood stasis(14.61%), spleen vacuity withphlegm-damp(14.61%), liver-qi invasion(10.11%) and kidney yang deficiency(8.99%) soon.Conclusion:The hypothyroidism patients account for29.77%in131PCOS patients.Hypothyroidism influences clinical manifestations of the PCOS patients by insulinresistance and glucose-lipid metabolism disorder.The linear regression analysis shows thatserum TSH level is closely related to insulin resistance. PCOS is closely related with liver,spleen and kidney, which is based on kidney deficiency. At the same time, blood stasis andphlegm dampness are the main pathological product about PCOS. Kidney yang deficiencyis the main syndrome in PCOS patients with hypothyroidism. Euthyroidism is kidney qideficiency.