Studies Of Cardiovascular Risk Factors In Polycystic Ovary Syndrome And PCOS Combined With Subclinical Hypothyroidism Paitents

Objective To invastate the relationship between resting heart rate and cardiovascularrisk factors in patients with polycystic ovary syndrome.Methods There were77patients who were diagnosed with PCOS in Department ofReproductive,Navy General Hospital from August2011to June2012,and73healthywomen volunteers enrolled in the study.Serum levels of lipids,fasting bloodglucose,blood glucose after meal,fasting insulin and insulin after meal weremeasured,and body weight,blood pressure,resting heart rate werecalculated.Independent-samples T-test and partial correlation analysis were used toevaluate the relationship between resting heart rate and cardiovascular risk factors inpatients with PCOS.Results (1)The resting heart rate,body mass index(BMI),blood pressure CarotidArterial Intima-Media Thickness(CIMT),blood glucose and insulin in PCOS groupwere significantly higher than in control [(82.09±7.86)/min vs (79.55±5.66)/min,P<0.05].(2) The resting heart rate was significantly correlated with BMI, systolic pressure,fasting insulin,insulin after1hour meal,and Triglyceride, Carotid Arterial Intima-MediaThickness(CIMT),(correlation coefficient:r0.177,0.191,0.199,0.204,0.216,0.196allP<0.05). (3)The resting heart rate, systolic pressure, Carotid Arterial Intima-Media Thickness(CIMT)，lipids and blood glucose after1h in non obese group of PCOS weresignificantly higher than obese group of control through divide2groups into4subgroups(Obses group and non obese group respectively);(4)After exclusion of confounding factors,such as BMI, diastolic pressure, CarotidArterial Intima-Media Thickness(CIMT)，fasting blood glucose,fasting insulin and soon,the increase of systolic pressure(β=0.237) and triglyceride levels(β=0.222) wereindependent risk factors for resting heart rate(P<0.05) by multivariate linear regressionanalysis.Conclusions The increased resting heart rate in PCOS group was significantlycorrelated with Carotid Arterial Intima-Media Thickness，Blood glucose and lipid. Theincreased Carotid Arterial Intima-Media Thickness, increased of systolic pressure andtriglyceride levels and increased resting heart rate may be independent risk factors toinduce cardiovascular in PCOS. Objective To invastate the change of Glycolipid metabolism and Carotid ArterialIntima-Media Thickness in polycystic ovary syndrome (PCOS) combined withSubclinical hypothyroidism(SCH).Methods There were54patients who were diagnosed with PCOS+SCH indepartment of Reproductive Medical Center,Navy General Hospital from October2011to June2012,and52women who diagnosed with PCOS enrolled in the study.Serum levels of lipids, Carotid Arterial Intima-Media Thickness(CIMT), fasting bloodglucose,blood glucose after meal,fasting insulin and insulin levels after meal weremeasured,and body weight,blood pressure, resting heart rate werecalculated.Independent-samlies T-test and partial correlation analysis were used toevaluate the change of Glycolipid metabolism and Carotid Arterial Intima-MediaThickness in patients with PCOS+SCH.Resutls (1) The resting heart rate, insulin levels in PCOS+SCH were higher thanthose in PCOS group(P<0.01).TSH,TG,insulin levels after1h meal in PCOS+SCHwere significantly higher than those in PCOS(P<0.05). Carotid Arterial Intima-MediaThickness(CIMT)was thicker in PCOS+SCH.(2) The resting heart rate,insulin levels after1h in BMI≧23subgroup in PCOS+SCHwere higher than those in BMI≧23subgroup in PCOS(P<0.05).TSH,TG in BMI≧23subgroup in PCOS+SCH were significantly higher than those in BMI≧23subgroup inPCOS(P<0.01). Carotid Arterial Intima-Media Thickness(CIMT)was thicker in PCOS+SCH(P<0.05). TSH(P<0.01) and CIMT(P<0.05) in BMI≦23subgroup inPCOS+SCH was significantly higher than those in BMI≦23subgroup in PCOS.(3)TSH of PCOS+SCH was significantly correlated with TG,HDL, CIMT, fastinginsulin and insulin after1h meal(correlation coefficient: r0.360、-0.259、0.327,0.408、0.255，all P<0.01).Conclusions PCOS+SCH patients may have more severe abnormal in Glycolipidmetabolism and significant changes in Carotid Arterial Intima-Media Thickness. TG,HDL and insulin levels may become independent risk factors for them.