Clinical Research By Applying The Qingwei Huoxue Granules In Treating The Moist Heat And Blood Stasis Syndrome Of Chronic Atrophic Gastritis

Objective：To observe the clinical effect and safety by using the QingWei HuoXueGranules in treating Moist Heat and Blood Stasis Syndrome of Chronic AtrophicGastritis,exploring the mechanism,to provide a reliable clinical evidence and guidance fortreating CAG by using Traditional Chinese Medicine.Methods：This research was based on104cases of outpatients who were conformedto inclusion criteria. They were randomly divided into two groups. One group was testgroup,53patients of which were treated with QingWei HuoXue Granules. The other groupwas the control group,with51patients being treated with WeiFuChun Tablet. Both groupswere treated for three months.Observing the curative effect of the clinicalsymptoms,gastroscopy signs and pathology,the eradication rate of H.pylori,and thehemorheology after one course of treatment,then analyzed them statistically.Result：1.The overall curative effect comparison of two groups after the treatment：The total effective rate of test group was90.57%, while the total effective rate of controlgroup was68.63%.There was statistically significant difference between the test groupand control group(P＜0.05). The effective rate from the test group was clearlysuperior.2.Comparison within groups found：Excepting nausea or vomiting was of noavail(P＞0.05), both of the two groups had curative effect to the other syndromes(P＜0.05).Comparison between groups found：The test group has symptomatic improvement instomach bloated,stomach pain,and tongue manifestation,stomach cauma,viscous or dilutestool. The comparison of two groups had statistical significance(P＜0.05or P＜0.01).Bothtwo groups had the same efficacy in bitter mouth or halitosis,nausea or vomiting and dim complexion(P＞0.05).The time of test group on alleviating stomach bloated,tonguemanifestation, and dim complexion was shorter than the control group, Other syndromeshad curative effect almost in the same time of the two groups.3.The two groups bothreexamined the gastro fiberscope,and the comparison of curative effect of two groups ofhistopathology,Hp and hemorheology after the treatment found：both groups had equivalenteffects in gastroscopy signs(P＞0.05). The total efficiency of gastric atrophy，intestinalmetaplasia of two groups was66.04%and69.81%respectively,while the control groupwas45.10%and49.02%respectively.The comparison of two groups had statisticalsignificance(P＜0.05).The improvement rate of inflammatory activity of test group wasalso better than the control group(P＜0.05).But the curative effect of dysplasia,chronicinflammation and H.pylori eradication rate between the two groups had no obviousstatistical significance(P＞0.05).After treatment,the hemorheology between two groupshad significant differences(P＜0.05).That meant the effect of test group was much moresignificant than the control group.Conclusion:QingWei HuoXue Granules was much more effective than WeiFuChunTablet in treating Moist Heat and Blood Stasis Syndrome of CAG.The prescription canimprove clinical symptoms and pathology.It can inhibit the inflammatoryresponse,improve gastric mucosal microcirculation, protect the gastric mucosa, block andreverse the precancerous lesionsbesides.It had been certified a safe and effectiveprescription by clinical experiment，and it is worth promoting.