The Relationship Between The Level Of Serum S100A8/A9 With The Lesion Severity And Coronary Lesion Branches Of Coronary Heart Disease

Objective For the early diagnosis of coronary heart disease and providing certain reference value to judge coronary artery disease severity, we investigated the relationship of serum S100A8/A9 with coronary artery lesion severity and lesion branches by detecting serum S100A8/A9 levels in coronary heart disease patients.Methods The research objects included 116 inpatients who be hospitalized due to chest discomfort and underwent diagnostic coronary angiography from March 2014 to August 2014 in Department of Cardiology Disease of the Second Affiliated Hospital of University of South China, according to the results of coronary angiography they were divided into coronary heart disease(CHD) group with 48 patients, coronary atherosclerosis(CAS) group with 42 patients and normal control group(NC) with 26 cases. According to coronary lesion count shown in coronaryangiography, the patients in CHD group was divided into three subgroups: single-branch vessel disease, double-branch vessel disease, three-branch vessel disease. To study the relationship of S100A8/A9 with the severity of coronary artery disease, in accordance with the Gensini scoring criteria for coronary lesion score, all the selected candidates were divided into normal control group, mild lesions, moderate lesions and severe lesions. All patients age, gender, clinical data, other laboratory results, CRP after admission and serum S100A8/A9 level were collected and statistically analyzed.Results(1) Serum S100A8/A9 levels were significantly increased in CHD group than CAS group and the healthy control group(P <0.05), serum S100A8/A9 levels were also significantly increased in CAS group than the normal control group(P <0.05).(2) According to the results of Gensini score all study were divided into normal control group, mild lesion group, moderate lesion group and severe lesion group, among the four groups of serum S100A8/A9 level, pairwise comparisons were significantly different(P <0.05). Here, it was shown that Serum S100A8/A9 levels was significant positive correlated with Gensini score(r=0.813, P<0.05).(3) In the three subgroups of patients with coronary heart disease, serum S100A8/A9 level was significantly higher in three-branch vesseldisease than the double-branch vessel disease and single-branch vessel disease(P<0.05), and serum S100A8/A9 levels in double-branch vessel disease was significantly higher as comparison with single-vessel disease group(P<0.05).(4) Serum S100A8/A9 levels was significantly positive correlated with CRP(r=0.498,P<0.05).Conclusion The results indicate that serum S100A8/A9 can display coronary artery lesion severity and lesion branches in CHD patients, so it may be used as a valuable marker for coronary heart disease and predict the severity of coronary artery disease.