Analysis On The Influence Factors Of Coronary Heart Disease And Lesion Severity Of Coronary Artery

Objective: To explore the dangerous factors of coronary artery lesions and the influence of coronary artery lesions by the gathering for coronary heart disease(CHD) risk factors, provide an evidence-based basis for the prevention and control of CHD.Methods: Collection the information of patients who were diagnosed as CHD by circulation department of one hospital in 2012.6—2014.6, understand the general situation of coronary lesions of patients and analyze risk factors for coronary artery pathological changes, analyze the independent risk factors of coronary heart disease(CHD) by Logistic regression model and study the influence of the gathering of different independent risk factors to coronary artery lesions.Results: The total number of the objects of the study is 434, including 262 men, accounted for 60.4%; and 172 Women, accounted for 39.6%. Average age was 60.64±11.48, the minimum age was 30 years old, the biggest age was 88, the research objects of 51-60 years old had the largest number, accounted for 35.5%, and ~40 and ~81 years old groups had the less number, accounted for 3.0% and 3.2% respectively. There were 310 patients who has coronary artery stenosis≥50%, accounted for 71.4%. Lesions of patients with CHD usually involve more than one vessels, and the degree of stenosis mainly concentrated in severe stenosis; Compared to people who have an CHD and those who do not, the differences of their age, sex, smoking history, drinking history, hypertension, family history of coronary heart disease, diabetes, HDL-C, c-reactive protein, homocysteine, heart rate, blood uric acid and overweight have statistical significance(P<0.05); Yet the differences of body mass index(BMI), TC, LDL- C in the two groups have no statistical significance(P > 0.05). The differences of gender distribution, HDL- C, fasting glucose, C- reactive protein and homocysteine in various coronary artery stenosis degrees were statistically significant(P<0.05). The differences of gender distribution, blood uric acid, HDL- C, fasting glucose, c-reactive protein and homocysteine and heart rate of the number of the vessels involved in various coronary artery lesions were statistically significant(P<0.05). Logistic regression analysis results of coronary heart disease risk factors showed that the model fitting has significance(c2 = 70.239, P < 0.001), and high blood pressure and high c-reactive protein are independent risk factors for coronary heart disease. Analyzing the number of independent risk factors of research objects, the results showed that there were 179 patients with no danger factors, accounted for 41.2%, 190 patients with any one risk factors, accounted for 43.8%, 65 patients with any two risk factors, accounted for 15.0%. With the increase of the gathered number of independent risk factors for coronary artery disease, the positive rate of coronary heart disease(CHD) has grown to 100% from 43.0%, the percentage of multivessel lesions has grown to 52.3% from 17,3%, the percentage of occluded lesion has grown to 44.6% from 10.6%.Conclusion: The number of vessels of coronary artery lesion is related to gender, blood uric acid, HDL- C, fasting glucose, c-reactive protein, homocysteine and heart rate; The degree of coronary artery stenosis is related to gender, HDL-C, fasting glucose, c-reactive protein and homocysteine; High blood pressure and high c-reactive protein are independent risk factors for coronary heart disease; The more independent risk factors for coronary heart disease(CHD) gathered, the bigger the positive rate of coronary artery disease, the more serious the degree of coronary artery lesion, the bigger the scope of coronary artery lesions.