Correlation Analysis Between The Body Mass Index And Cancer

BackgroundThese days, the incidence of overweight and obesity is increasing, which is a serious threat to health. Much research has shown that obesity is one of the dreadful risk factors, which increases the risk of a variety of malignant tumors, such as diabetes, however, as the most common substitute for obesity Index, Body Mass Index (BMI) can reflect the clinical features and prognosis of obese patients with tumor well. Nowadays, the conclusion of clinical research on the relationship between Body Mass Index (BMI) and of malignant tumor is not consistent. Obesity is a risk factor for a variety of malignant tumors, but the correlation mechanism is not clear, which is also the central issue for researchers both at home and abroad to study.ObjectiveThe objective is to study the correlation between Body Mass Index (BMI) and malignant tumors, as to provide the theoretical basis for reducing the occurrence of malignant tumors.Methods 265 patients who were diagnosed with malignant tumor by the pathology in the third affiliated hospital of Xinxiang Medical University from January 2012 to January 2015 are selected and divided into different groups according to the position of the tumor. And another 135 people without cancer or cerebrovascular disease in the hospital physical examination center are selected as a control group. The average BMI value is calculated according the weight and height. And the average BMI value of the research group and the control group are compared and analyzed with SPSS19.0 software (P<0.05 was statistically significant).Results1 There were 265 patients with malignant tumor in the research group, which consist of 60 cases of colorectal cancer,56 cases of esophageal squamous cell carcinoma,22 cases of cardiac cancer,33 cases of breast cancer,43 cases of lung cancer,20 cases of liver cancer,16 cases of cervical carcinoma,8 cases of ovarian cancer, and 7 cases of gastric carcinoma. And the corresponding average BMI values were (25.95±1.929)kg/m2, (20.72±3.089)kg/m2,(25.05±1.508)kg/m2,(25.53±2.995)kg/m2,(24.01±3.348)kg/m2,(23.28 ±3.437)kg/m2, (24.26±3.492)kg/m2, (22.66±2.456)kg/m2, (22.47±4.509)kg/m2.The average BMI value in control group (67male and 68 female) is (22.330±2.405)kg/m2. The BMI of patients with colorectal cancer, esophageal squamous cell carcinoma, cardiac cancer, and breast cancer patients were signifantly different compared to the control group, which were statistically significant (P<0.01), while the BMI of patients with lung cancer, liver cancer, cervical cancer, ovarian cancer, and gastric cancer were not statistically significant (P>0.05) compared to the control group.2 Patients were divided into groups according to age. Comparing the BMI of the colorectal cancer group, lung cancer group, esophageal squamous carcinoma group with the control group(1) The BMI of patients younger than 60 or older than 60 with colorectal cancer had statistical significance (P<0.01) compared with the control group, which showed that the BMI of patients with colorectal cancer is higher than that of the control group.(2) The BMI of patients younger than 60 with esophageal squamous cell carcinomas had no statistical significance (P>0.05) compared with the control group. However, the BMI of patients older than 60 with esophageal squamous cell carcinomas had statistical significance (P<0.01) compared with the control group.(3) The BMI of patients younger than 60 or older than 60 with lung cancer had no statistical significance (P>0.05) compared with the control group, which showed that the relationship of the BMI between the lung cancer group and the control group was not signifant after being divided into groups according to age.3 Logistic regression analysis of colorectal cancer, and breast cancer risk factor(1) The increase of BMI is a risk factor for colorectal cancer occurrence (OR=1.04,95% CI:1.07～1.58).(2) The increase of BMI is a risk factor for breast cancer occurrence (OR=1.06,95% CI: 1.126～1.495).ConclusionsThere is close relationship between BMI and malignant tumors, and it could lead to malignant tumor much easier if the BMI is too high or too low. Exercise is suggested for controlling the BMI value and reducing the incidence of malignant tumor.