A Meta-Analysis Of The Correlation Between Obesity,Body Mass Index And Ovarian Malignancy

Objective: To find the correlation between body mass index and ovarian malignant tumors through a meta-analysis system.Research method: By searching Pubmed,Cochrane Library,China Knowledge Network(CNKI),Chinese Biomedical Literature Database(CBM),etc.Before July,the retrieved documents were screened,and the corresponding original data in the documents were extracted and analyzed using RevMan 5.3 software.Results: After strict selection and exclusion criteria screening,a total of 12 case-control studies were included in this article.According to the World Health Organization(WHO)criteria,the body mass index(BMI)was divided into 3 groups,<25 was the normal weight group,and 25-29.9 was overweight,≥30 was obese.The risk of ovarian cancer in the obese group was 1.17 times that of the normal-weight group(OR = 1.17,95% CI [1.11,1.24],Z = 5.70,P <0.00001),and 1.16 times in postmenopausal women(OR = 1.16,95% CI [1.05,1.28],Z = 3.00,P = 0.003).In premenopausal women,the risk of ovarian cancer from overweight was 1.23 times that of the normal-weight group(OR = 1.23,95% CI [1.10,1.38],Z = 3.50,P = 0.0005),and the r isk of obesity group was 1.51 times(OR = 1.51,95% CI [1.33,1.70],Z = 6.58,P <0.00001).In the early adulthood of the overweight population,the risk of ovarian cancer in the future is 1.17 times that of the normal-weight group(OR = 1.17,95% CI [1.07,1.28],Z = 3.54,P = 0.0004).The risk of disease in the obese group is weight Normal group population 1.28 times(OR = 1.28,95% CI [1.09,1.49],Z = 3.10,P = 0.002).For patients with mucinous ovarian cancer,the risk of disease was 0.83 times lower for patients with overweight than those with normal weight(OR = 0.83,95% CI [0.71,0.97],Z = 2.38,P = 0.02).The risk of ovarian cancer in fertile,oral contraceptive,and tubal ligation patients is reduced.People with hysterectomy and family history of ovarian cancer have an increased risk of ovarian cancer.CONCLUSION: Obese people have an increased risk of ovarian cancer,which is more pronounced in premenopausal women.