The Correlation Research About Type A Behavior And Quality Of Life In GD Patients

Objective:GD is a one of the autoimmune thyroid diseases which are the most common organ-specific autoimmune disorders, stress plays an important role in etiology of Graves hyperthyroidism, and GD is one of the classic psychosomatic disease. Research in china and abroad found that the personality characteristics of patients with GD are much more "A" type behavior. The quality of life has decreased obviously in patients with GD. The number of clinical symptom, age and educational level were the major social and clinical factors, which effect the quality of life of patients with Graves disease. However, the relationship between Type A behavior and the quality of life in patients with GD have not been reported in china. To explore the relationship between Type A behavior and quality of life(QOL) of patients with GD. In order to provide evidence for the psychological treatment of patients with GD.Methods:According to the inclusion and exclusion criteria, a total of 80 newly diagnosed patients with GD from September 2013 to June 2014 in our hospital were enrolled in this study. 80 normal subjects from our health center are matched based on the general information of GD. All the healthy individuals are tested with Thyroid hormone, in order to exclude Thyroid dysfunction. Then according to the grading standard of type A behavior questionnaire, group of GD will be divided into the type A behavior group and non type A behavior group, and the same as control group. All Subjects were administered a standardized questionnaire that provided information about their name, sex, age,occupation, marital status,education level,monthly income and history of thyroid disease and so on. In addition, outpatients are investigated with Short Form 36 questionnaire before drug therapy, and patients in hospital tested the moment they got into the hospital. All data were analyzed by SPSS(version17.0) using chi-square for categorical variables and independent t text for continuous variables. Continuous variables were expressed as mean±standard deviation. Categorial variables were presented as ratio or constituent ratio. Multiple stepwise regression analysis was performed to investigate the impact of personality factors, risk factors of quality of life of GD patients. P value of < 0.05 was used for all tests to indicate statistical significance.Results:(1)We eventually selected valid questionnaires 160 subjects, the mean age(44.25±10.81),There were no significant differences between two groups in sex, educational level, occupation, economic conditions and so on(t=1.96,P=0.061;χ2=0.79,P=0.851;χ2=1.23,P=0.754;χ2=0.49,P=0.971; χ2=0.27,P=0.383).(2) Of GD patients,the distribution frequency of type A behavior is 65.0%, which was higher than the control group16.3%, has a statistically significant difference(χ2=30.92,P<0.001).(3) The scores of physicalfunctioning(PF),role-physical(RP),bodily-pain(BP),genera-health(GH)vitality(VT), social-functioning(SF), role-emotional(RE), mental-health(MH) in patients with GD were lower than the normal subjects, with significant difference(t=-6.71,P<0.001;t=-3.40,P<0.001;t=-6.60,P<0.001;t=-6.71,P<0.001;t=-7.44,P<0.0001;t=-4.33,P<0.001;t=-4.67,P<0.001;t=-2.61,P<0.05;t=-8.13,P<0.0001):in GD group, the scores of physical functioning(PF),role-physical(RP),bodily-pain(BP),genera-health(GH)vitality(VT), social functioning(SF), role emotional(RE), mental-health(MH) in patients with Type A behavior were lower than the non Type A behavior, with significant difference(t=-5.32, P<0.001;t=-3.40, P<0.002; t=-9.04, P<0.001; t=-8.63,P <0.001; t=-10.35, P<0.001; t=-8.10, P<0.001; t=-15.38, P<0.001; t=-2.25, P<0.05; t=-4.51, P<0.001) :in normal group, the scores of physical functioning(PF),role-physical(RP),bodily-pain(BP),genera-health(GH)vitality(VT), social functioning(SF), role emotional(RE), mental-health(MH) with Type A behavior were lower than the non Type A behavior(t=-2.89,P<0.001;t=-0.08,P=0.931;t=-0.43,P=0.672;t=-0.38,P=0.702;t=-1.96,P=0.064;t=-1.39,P=0.177; t=-1.77,P=0.088; t=-1.07,P=0.283; t=-1.91,P=0.061), but only PF with significant difference.(4)Multiple stepwise regression analysis showed that type A behavior, educational level, gender differences and financial situation were entered QOL regression equation(β=-5.74、7.20、1.82、3.94, P<0.05). Our research showed that type A behavior, educational level effected the quality of life with patients of GD. Type A behavior has negatively correlated with quality of life with GD, educational level has positively correlated with quality of life with GD.Conclusion: 1. The majority of behavior pattern of patients with GD is type A behavior. 2. The quality of type A behavior patients with GD is signifycantly lower than non type A behavior GD patients.