| Objective:Clinical Efficacy of acupuncture combined treatment of perimenopausal syndrome and levels of sex hormones, neurotransmitters affect the content, quality of life for the future promotion of acupuncture in clinical interventions combined to provide the basis of perimenopausal syndrome.Methods:100 patients diagnosed with perimenopausal syndrome patients, the 95 patients enrolled were randomly divided into 32 cases in acupuncture combined group.31 cases in Chinese medicine group and 32 cases in acupuncture group. Acupuncture combined with Chinese medicine and acupuncture group received combination therapy.Namely:to give oral self-made "he shu tiao geng wan" treatment, on the 30th for a course of treatment, a total of three courses of treatment (3 months). Tianshu acupoints acupuncture, according to the sea, the customs, Sanyinjiao, five-axis, treatment 6d for a course of treatment after a break for the next course 1d, were treated with 12 courses (three months).TCM group was given oral self-made " he shu tiao geng wan " treatment, on the 30th for a course of treatment, a total of three courses of treatment (3 months) Acupuncture group:tianshu acupoints acupuncture, according to the sea, the customs, Sanyinjiao, five-axis, treatment 6d for a course of treatment after a break for the next course 1d, were treated with 12 courses (three months).Three groups of patients before and after treatment of clinical symptoms and signs, symptom scores, improved Kupperman score, sex hormone levels [estradiol(E2)levels of follicle stimulating hormone (FSH), luteinizing hormone (LH)], nerve neurotransmitter content [plasma β-endorphin (β-EP) levels,24h urinary norepinephrine (NE),5- hydroxytryptamine (5-HT) content] quality of life (MENQOL) dimensions and perimenopausal syndrome score.Results:Acupuncture combined total effective rate was 93.75%, traditional Chinese medicine group, the total effective rate 70.97%, acupuncture group, the total effective rate 68.75%, the difference was significant (P<0.05).Kupperman scores improved after treatment than before treatment was significantly decreased (P< 0.01); between treatment groups improved Kupperman scores, significant (p<0.05). Kupperman scores between the treatment gro ups,acupuncture combined group and the other two groups was significant (P<0.05),Chinese medicine group and acupunture group not statistically significant (P>0.05). After treatment significantly reduced symptom scores than before treatment (p<0.01); symptom scores after comparison between treatment groups was significant (P<0.01),Chinese medicine group and acupunture group not statistically significant (P>0.05). After treatment, acupuncture combined group serum estradiol (E2) levels significantly higher than those before treatment (P< 0.01),Chinese medicine group and acupunture group not statistically significant (P>0.05),but there is an upward trend, After treatment serum estradiol (E2) levels comparison acupuncture combined group and the other two groups was significant (P<0.05),Chinese medicine group and acupunture group not statistically significant (P>0.05). After treatment, acupuncture combined group serum follicle stimulating hormone (FSH) levels lower than those before treatment(P<0.05), Chinese medicine group and acupunture group not statistically significant (P>0.05), After treatment serum follicle stimulating hormone (FSH) levels comparison acupuncture combined group and the other two groups was significant (P<0.05),Chinese medicine group and acupunture group not statistically significant (P>0.05). After treatment,the three groups luteinizing hormone (LH) levels have decreased than before treatment,but (P>0.05), no statistically significance; After treatment, luteinizing hormone (LH) levels of comparison, (P>0.05), no statistically significance. After treatment, plasma (3-endorphin (β-EP) levels significantly higher than those before treatment (all P< 0.01); compare plasma β-endorphin (β-EP) levels between the treatment groups, with significant sex(P< 0.05),namely acupuncture combined group better than the other two groups, Chinese medicine group better than acupunture group. After treatment,24h urinary norepinephrine (NE) significantly lower than those before treatment (all p<0.01); compare 24h urinary norepinephrine (NE) between the treatment groups, with significant sex (P<0.05),namely acupuncture combined group better than the other two groups, Chinese medicine group better than acupunture group. After treatment,5 - hydroxytryptamine (5-HT) content significantly lower than those before treatment (all p<0.01),5- hydroxytryptamine (5-HT) content between the treatment groups,acupuncture combined group and the other two groups was significant (P<0.05),Chinese medicine group and acupunture group not statistically significant (P>0.05). After treatment, MENQOL vasomotor dimensionality scores significantly lower than those before treatment (all P< 0.01); compare MENQOL vasomotor dimensionality scores between the treatment groups, with significant sex(P< 0.01),namely acupuncture combined group better than the other two groups, Chinese medicine group better than acupunture group. After treatment, MENQOL psychological dimensionality scores significantly lower than those before treatment (all P< 0.01), MENQOL psychological dimensionality scores between the treatment groups,acupuncture combined group and the other two groups was significant (P<0.01),Chinese medicine group and acupunture group not statistically significant (P>0.05). After treatment, MENQOL physiological dimensionality scores significantly lower than those before treatment (all P< 0.01), MENQOL physiological dimensionality scores between the treatment groups,acupuncture combined group and the other two groups was significant (P<0.01),Chinese medicine group and acupunture group not statistically significant (P>0.05). After treatment, MENQOL sex life dimensionality scores significantly lower than those before treatment (all P<0.01); compare MENQOL sex life dimensionality scores between the treatment groups, with significant sex (P<0.01),namely acupuncture combined group better than the other two groups. Chinese medicine group better than acupunture group.Conelusion:Chinese medicine,acupunture and acupuncture combined therapy can improve perimenopausal syndrome symptoms, signs and TCM syndrome, increased plasma β-endorphin (β-EP) levels, lower 24h urinary norepinephrine(NE),5- hydroxytryptamine (5-HT) content, improve the quality of life of patients. acupuncture combined therapy can increase serum estradiol (E2)levels, decreased serum follicle stimulating hormone (FSH) levels. Chinese medicine and acupunture therapy serum estradiol (E2) levels rise, can not decrease serum follicle stimulating hormone (FSH) levels.All three methods can not decrease luteinizing hormone (LH) levels. Acupuncture with combination therapy, not only will not antagonize the effect of both, and can be complementary, synergistic, is an effective method and means of clinical intervention perimenopausal syndrome. |
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