Correlation Analysis Of Total Fluid Input, Sodium Containing Liquid, Dehydrating Agent And Blood Sodium And Prognosis Of Patients With Craniocerebral Injury Combined With Hypernatremia

Objectives :This study aimed to investigate recovery of blood sodium in craniocerebral patients combined with hypernatremia and the correlations among prognosis、total fluid input、sodium containing liquid and dehydrating agent.In order to provides evidence-based treatment for this group of patients with clinical liquid management.Methods :This study is a retrospective cross-sectional study. We selected 133 cases of craniocerebral injury patients with hypernatremia from three hospitals neurosurgery from January 2014 to December 2014. The basic information collected mainly includes clinical data of hypernatremia in the day(hereinafter referred to as clinical data). The total amount of intravenous fluids appeared after the high blood sodium every day in the 3d(3d for short), fluid input(rehydration amount plus the digestive tract water intake), sodium containing liquid intake and dehydrating agent used, and the duration of abnormal blood sodium, discharge Glasgow prognostic score(Glasgow Outcome Scale,GOS), etc.Results :1 The serum sodium recovery time was 6.61 ±6.20 days(3 ~49 days). Patients were divided into two classes when they discharged according to GOS. The good prognosis are107 cases(80.5%) who can fluent speak and write. The poor is 26 cases(19.5%).2 There was a negatively correlation between patients with hypernatremia day Na liquid and the intake of mannitol and serum sodium recovery time(P < 0.05).3 Prognosis(1) Into the fluid input, transfusion amount, sodium containing liquid content, the dosage of mannitol and the prognosis of the patients with different degree of correlation.(2) The prognosis of patients was statistically significant difference between groups whose into the liquid quantity < 3000 ml and ≥3000 ml, infusion volume < 3000 ml and≥3000 ml, sodium containing liquid content < 2200 ml and ≥2200 ml, mannitol < 400 ml and ≥400 ml.4 The value of serum sodium and serum sodium recovery time when hypernatremia occurred were positively correlated.5 Serum sodium value has significant correlation with outcome.Conclusion:With high natremia of craniocerebral injury patients into the liquid, the liquid sodium intake and dehydrating agent amount associated with serum sodium recovery and prognosis. Clinical medical staff should comprehensively considerate patients with high craniocerebral injury and formulate appropriate rehydration solution as early as possible, in order to improve the prognosis of patients.