Application Of Fluid Therapy Treatment Of Severe Traumatic Brain Injury Research

This thesis consists of two parts: the one is the review summaries which covering theunderstanding treatment and the lately progresss in the recently ten years aboutcraniocerebral injury, the other one is the clinical studies.Craniocerebral injury is caused by outside violence and its occurrence anddevelopment depend on the factor and property of the damages. There are a lot ofmethods to classify the craniocerebral injury. It can be devided into primary braininjury and secondary brain injury. The former is the result of direct or indirect violencein the head. Direct hit in the head can lead to three kinds of damages including injuryof acceleration, injury of deceleration and crush injury. Indirect violence also resultsin serious brain injury. The latter includes traumatic cerebral edema and tardiveneuronic damages. Damages of blood-brain barrier, calcium overloading, increase ofoxyradical, lipid peroxidation are the reasons that develop the traumatic cerebraledema. Abnormal transmitter or acceptor, lipid peroxidation and calcium overloadingalso can make neuron necrosis or apoptosis.The patients with opened craniocerebral injury or those with closedcraniocerebral injury with intracranial hematoma need operating. A lot ofcraniocerebral injury patients need non-operation. Even Patients after surge alsoneed non-operation, which more complicated than operating. Only in this way can thetreatment be success. They always need to be lowered intracranial pressure andthey are treated with ehydrater, hormone, oxygen, lytic cocktail or hypothermia, etc.Sedative, anti-epileptic, NSCtransplanting, antibiotic, nutritional support and thetherapy of complication are of importance to them.The objective of this research is to value the effect of the prescription for treatingsevere craniocerebral injury. Methods: thirty patients were randomly divided into twogroups. The treatment group (n=15) was treated by the prescription with balanceliquid plus colloidal liquid plus dehydrating agent. The control group (n=15) wastreated with dehydrating agent alone. Detect the blood pressure and TCD data beforeand after infusion on the patients. The result indicates that average Cerebralperfusion pressure of the treatment group increased 10.80±4.84mmHg and averageCerebral perfusion pressure of the control group increased 7.13±3.29mmHg.Conclusion: the prescription with balance liquid plus colloidal liquid plus dehydrating agent is able to improved significantly the cerebral perfusion of the patients of severecraniocerebral injury.