The Clinical Observation About The Influence Of The Fangji Huangqi Capsule On The Blood-uric-acid Level Of The Phlegm-dampness-type Hypertension

Objectives:The research objectives are the influence of the Fangji Huangqi Capsule on the blood pressure,blood-uric-acid level and the drain of uric acid of those patients, and the relativity between the Phlegm-dampness-type hypertension and the blood-uric-acid level.Methods:First, work out the Syndrome diagnostic criteria of the Phlegm-dampness-type hypertension according to the Guiding Principles of New Medicine Clinical Research in Chinese Traditional Medicine, and design the unified Chinese medicine symptom rating scale. In addition, collect 59 relative cases from the cardiovascular internal ambulant departments and the in-patient departments in the third affiliated hospital of Henan University of Chinese Medicine and Anyang Chinese-Medicine Hospital. Besides, give the further symptom scores; measure blood pressure, blood-uric-acid and uric acid levels. Second, by adopting the method of randomized controlled trials, distribute the eligible subjects in the ratio of 1:1 among the treatment group(30 cases) and the control group(29 cases). The treatment group adopts the treatment of captopril + the Fangji Huangqi Capsule, while the control group only adopts the treatment of captopril. The course of treatment last 6 weeks. Record the symptom rating scores, blood pressure,blood-uric-acid and uric acid levels respectively after the treatment. Last,input the patients’ general information, blood pressure, blood-uric-acid,uric acid levels and the Chinese medicine symptom information into the statistical software; observe the distribution of the age and sex in the 2 groups; do the statistical analysis on the changes of blood pressure, blood-uric-acid,uric acid levels and the Chinese medicine symptom rating scores.Results:There is no significant difference on the patients’ sex, age and course of disease between the treatment group and the control group(P>0.05). On the blood pressure, before the treatment, there is no significant difference among the systolic pressure, diastolic pressure and the average blood pressure in the treatment group and the control group(P>0.05).After the treatment, there is significant difference upon the systolic pressure and the average blood pressure(P<0.01), while there is no significant difference on the diastolic pressure both in the treatment group and the control group(P>0.05). On the blood-uric-acid and uric acid level, before the treatment, there is no significant difference in both the treatment group and the control group( P>0.05); while after the treatment, both blood-uric-acid and uric acid levels decrease significantly in both groups than that before the treatment(P<0.01), and there are more significant differences in the treatment group than in the control group(P<0.05). There is no relativity between the decrease of blood uric acid and the decrease of the urine uric acid(Pearson correlation coefficient r=0.23, P>0.05) in both groups.In both group the blood pressure will decrease with the decreasing of blood–uric-acid,but there is no correlation.On the Chinese medicine symptom rating scores,there is no significant difference between the two group before the treatment( P >0.05).After the treatment, the Chinese medicine symptom rating scores of the treatment group has significant difference than before treatment(P<0.05),but the Chinese medicine symptom rating scores of the control group has no significant difference than before treatment(P>0.05).There is significant differences between the control and the treatment group on the Chinese medicine symptom total rating scores(P<0.01). All the clinical symptoms except for the palpitation and insomnia, namely the single Chinese medicine symptom rating scores, decrease significantly in the treatment group(P<0.05).And there is significant difference upon the treatment efficiency of Chinese medicine symptom in the treatment group and the control group(P<0.01).Conclusion:The Fangji Huangqi Capsule can significantly decrease the blood pressure, the blood-uric-acid and the uric acid levels of those patients with the Phlegm-dampness-type hypertension, and improve their clinical symptoms.The patient’s blood pressure level will decrease with the decreasing of blood-uric-acid level,but there is no direct correlation between the decrease of blood pressure and the blood-uric-acid.