Clinical Research On The Mechanism Of Action On The Method To Chronic Atrophic Gastritis Caused By Spleen Deficiency

Objective: Chronic atrophic gastritis(chronic atrophic gastritis, referred to as the CAG) on gastric mucosa inherent glands atrophy thinning, mucosal muscularis, thickening, or associated with intestinal metaplasia, hyperplasia, etc for the main performance of a common digestive system disease, belong to the category of traditional Chinese medicine such as the new of stomach pain, stomach. The clinical manifestations of the CAG lack of specificity, and the degree is not completely consistent with pathological changes. As the fiber gastroscope pathological and histological study progress, and the advent of the CAG detection rate is on the rise and is listed as stomach precancerous condition. Modern medicine for the treatment of the disease is still lack of effective method at present. Of the disease and the motherland medicine through a large number of clinical and experimental research has obtained the remarkable curative effect. This topic aims to observe the walls of the stomach better mixture on the clinical efficacy of spleen deficiency chronic atrophic gastritis patients and the impact on the level of serum gastric secrete element, to study the mechanism of spleen deficiency chronic atrophic gastritis.Method: Choose 60 cases of confirmed patients with spleen deficiency chronic atrophic gastritis, with random number table method in clinic order divided into treatment group and control group. Treatment group of 30 patients, to give away the stomach ning mixture of oral; In the control group of 30 patients, give warm stomach shu capsule orally. Two groups of a course of 6 months. By comparing the two groups of patients before and after treatment under the electronic fiberscope gastric mucosa and gastric mucosa pathological histology, quantitative TCM syndrome integral and the change of the serum levels of gastric secrete element, to study the walls of the stomach better mixture mechanism of spleen deficiency chronic atrophic gastritis.Results: 1, baseline data before the treatment, two groups of patients with gender, age, course of the disease, Chinese medicine symptom integral, gastric mucosa pathological tissue, gastric secrete element values, etc., there was no significant difference(P > 0.05), comparable.2, gastric mucosa pathological effect comparison: after treatment, two groups of patients with gastric mucosa pathological have significant difference(P < 0.05), indicating that the treatment group is better than that of control group in terms of improve gastric mucosa pathological.3, TCM syndrome curative effect comparison: after treatment, two groups of patients with TCM syndrome curative effect have significant difference(P < 0.05), suggesting that both groups of TCM syndrome are improved, but the treatment group is better than the control group.4, serum gastric secrete element value comparison: after treatment, serum of two groups of patients with gastric secrete element values are higher than before treatment, but the treatment group is better than that of control group(P < 0.05).Conclusion: Through this topic research has found that weak stomach ning mixture clinical symptoms in patients with spleen deficiency chronic atrophic gastritis, gastric mucosa pathology and gastric secrete element values are obviously improved. And through the preliminary clinical studies concluded that spleen and liver and stomach law by promoting the secretion of serum gastric secrete element to promote the restoration of atrophic gastric mucosa.