| Objective: through the clinical application of Shentongzhuyu Decoction in the treatment of kidney deficiency and blood stasis type of knee osteoarthritis, to evaluate the therapeutic effect and is safe and reliable. This experiment use Shentong Zhuyu Tang, the addition and subtraction as the control group, the dialectical treatment of patients were observed before and after treatment, pain score(VAS score), "" reference standard of diagnosis and therapeutic effect of TCM and Lysholn and Gillquist knee evaluation standard, the medical system data analysis, evaluation of the prescription osteoarthritis of the knee(kidney deficiency and blood stasis type) is effective, whether it can provide a theoretical basis for the clinical application.Methods: cases from March 2013 and 2015 March Jilin Province Hospital of traditional Chinese medicine clinical diagnosis for patients with knee osteoarthritis(kidney deficiency and blood stasis type) were 60 cases, the treatment group was 30 cases and the control group(30 cases) was observed. Signed into the study of informed consent. In the two groups before treatment, there was no statistically significant difference(P>0.05) of the basic personal information(such as: gender, duration of disease, basic vital signs, etc.).Methods: patients in the treatment group, a detailed record of history, duration and the perfect routine examination, in line with the conditions, were randomly divided into two groups. Method: patients were randomly divided into two groups.(a) the treatment group For patients taking professor Li Xinjian’s clinical experience(Shentongzhuyu decoction treatment). The composition of 15 g from 15g: 25 g, notopterygium root, Rhizoma Chuanxiong, peach kernel 10 g, safflower 10 g, myrrh 10 g, FT 15 g, root 20 g, angelica 20 g, nutgrass galingale rhizome 10 g, licorice 8g, earthworm 10 g 20g 10 g, prepared rhizome of rehmannia, Chinese yam, Cornus officinalis cortex 10 g, 10 g. Day 1, decoction take liquid 200 ml 2 clothes, January / treatment. Lasted for 3 months, 3 courses. Do the daily nursing work, regular examination, and compared with before treatment, and record the case, regularly ask patients clinical symptoms and clinical symptoms of the patients were compared before treatment, and record.(b) in control group Control group: For knee osteoarthritis patients taking pill for relieving pain of clinical commonly used in the treatment of kidney deficiency and blood stasis type of knee osteoarthritis Chinese medicine bone hyperplasia: Long Wei medicine of words(94) 0530 number, main ingredients: prepared rehmannia root, Caulis Spatholobi, epimedium, radish seed and other, 2 times a day, each time a pill, after dinner with boiling water, oral, January / course. Continuous treatment for 3 courses. Do the daily nursing work, regular X-ray examination and the routine, and compared with the group before the examination, and record the case, regularly asked about the medication compliance of patients with clinical symptoms and into the group of patients with clinical symptoms contrast. And for the record. According to the evaluation of pain scale and Lysholn and Gillquist knee joint evaluation criteria, the daily work and quality of life were evaluated. Data analysis was conducted using the medical data analysis. The validity and safety of the system were analyzed.Results: 1, index of effect: before treatment(P > 0.05) scores of two groups no significant difference can compare, after treatment between the two groups had no difference(P > 0.05). The two groups were compared: therapeutic indexes. 2, curative effect comparison: the treatment group 2 people(6.67%), 16 people(53.33%), 8(26.67%), invalid 4 people(13.33%), a total of 30 people, 86.67%. In the control group, 1 persons(3.33%) were cured, 17 were markedly effective(56.67%), 7(23.33%) were effective, and 5(16.67%) were ineffective, and the effective rate was 83.33% and 30, respectively. The two groups was no difference(P > 0.05). The recipe treatment kidney deficiency and blood stasis type of KOA and hyperosteogeny analgesic pill treatment effect is quite. 3, the overall efficacy of satisfaction in comparison: the treatment group was very satisfied with 9 people(30%), 12 people(40%), not satisfied with 9 people(30%), very satisfied with the rate of 70%. In the control group, 8(26.67%) were very satisfied, 13(43.33%) were satisfied, 9(30%) were not satisfied, the satisfaction rate was 70%. The efficacy of the two groups was statistically P>0.05, and the effect of the groups was satisfactory.4, safety evaluation: two groups before and after treatment, laboratory examination and electrocardiogram is shown, that the party has no obvious change, for the treatment of osteoarthritis of the knee with less toxic side effect, it is safe to take.Conclusion: the prescription in the treatment of kidney deficiency and blood stasis KOA compound reinforcing rib is superior. To relieve the pain of patients, improve the quality of daily life and work, and has little side effect, can be widely used in clinical treatment. |
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