| Objective: This subject clinical trials using yu-ping-feng as a control, observed and further evaluation the clinical effectiveness and safety of hopane Gui soup prevention and treatment of syndrome of qi deficiency of spleen and lung of adult recurrent upper respiratory tract infections.Design method: According to the cases inclusion of research select 72 patients, randomized controlled observed treatment group and a control group of 36 cases each. The control group select to use yu-ping-feng; the treatment group select to use Chinese medicine hopane Gui soup. The treating course was two weeks. Observation and keep a record of clinical symptoms and related laboratory observation index changes before and after the treatment to make efficacy and safety evaluation.Results:(1) Basic information: in the comparison of basic information two groups of patients such as gender, age, the clinical course, attack time and Chinese medicine symptom score, there was no statistically significant difference( P>0.05); therefore we can consider the basic information of two groups patients as no difference with comparison.(2) TCM syndrome scoring: after treatment, the treatment group and the control group can be significantly improved symptom scores of the evil wind, spontaneous perspiration, poor appetite, abdominal distension after food, defecate pond, body tired weakness, cough, stuffy nose, runny nose, there was statistically significant difference between pretherapy and post-treatment(P<0.01); there were five symptom of score treatment group,include stuffy, spontaneous perspiration, poor appetite, abdominal distension after food, defecate pond and cough have improvement than the control group(P<0.05).(3) symptom total score: there werestatistically significant difference of total points in the two groups of patients between pretherapy and post-treatment(P<0.01); compared the two groups after treatment between, the result has statistically significant difference(P<0.01), indicating two groups medications is obviously improve the symptom of the patients after treatment, what’s more, the improvement of the treatment group is statistically better than the control group.(4) the efficacy of disease: After two weeks’ treatment, the total cure efficiency and total efficiency of the two groups were 8.82% and 97.06% in the treatment group, 3.03% and 39.39% in the control group. Comparison between the efficacy of group, the result has statistically significance(P<0.05). The treatment group was significantly better than the control group.(5) safety indicators: the blood routine, the urine routine, the stool routine, liver function and renal function of two patients groups before and after treatment have no abnormality; t-test showed that, after two weeks’ treatment groups’ blood routine WBC has declined, the difference has statistically significance(P<0.05), but the change of any one are all in the normal range; The rest of the security index before and after treatment there was no statistically significant difference(P>0.05).Conclusion:(1) The treatment group’s total efficiency was 97.06%, the control group’s total efficiency was 39.39%, the result indicates that Chinese medicine hopane Gui soup clinical curative effect is distinct.(2) in the process of this topic research observation, no patients became seriously ill, and no patients died, before and after treatment all patients’ blood routine, urine routine, stool routine, liver and kidney function did not appear abnormal, this suggests that the security of two kinds treatment are standard.(3) To qi deficiency of spleen and lung of adult recurrent upper respiratory tract infections, chinese medicine hopane Gui soup through its complement of lung qi, Jianpi with appetizers and consolidate the vigour can significantly improve symptoms, and its side effect is small. |
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