| Objective To explore the possible causes of road traffic injuries in Nanning, Guangxi, we investigated the relationship between the driver’s personality, psychology,5-HT2A/1B receptor gene polymorphisms and their accident proneness of RIT, aiming at providing a theoretical basis for reducing road traffic injuries in psycological and genetic aspects.Methods According to the inclusion and exclusion criteria, we used 1:1 match case-control study for selecting accident proneness drivers between 2008 and 2012 in Nanning, Guangxi. Three hundred patients and 300 controls were identified and their psychological conditions were assessed using personality questionnaire and SCL-90 scale while the polymorphism loci of T102C and A-161T in their 5-HT2A receptor gene and 5-H T1B receptor gene were investigated by the PCR-RFLP technique. Descriptive statistics were used to summarize the baseline characteristics of all cases in the cohort. EpiData3.0 and SPSS16.0 statistical software were used to establish database. Statistical analysis was performed using t test, chi square test, ANOVA, rank sum test and multivariate Logistic regression model analysis respectively.Results (1) The score of extroversion (E), mental quality (P) and emotional (N) was significantly higher in the accident group than in the control group (t= 5.57, P=0.00;t=2.29, P=0.02; t=2.17, P=0.03). (2)The score of somatization, obsession, anxiety, hostile and terror was significantly higher in the accident group than in the control group(t=3.73, P=0.00; t=4.39, P=0.00;t=2.27, P=0.02; t=3.22, P=0.00; t=2.27, P=0.03). (3)The score of E, somatization, obsession, anxiety and hostile of those drivers with driving experience> 15 years in the accident group was higher than the control group(P<0.05). (4)The score of E, P, somatization, obsession, anxiety and hostile of those drivers with junior middle school education in the accident group was higher than the control group(P< 0.05). (5)The multivariate logistic regression analysis showed that E(OR=1.41, 95%CI=1.18～1.69), hostile (OR=5.39,95%CI=1.49～19.56) and terror (OR=5.42,95%CI=1.45～20.25) were risk factors for accident proneness. (6)No difference in the genotype and allele frequency of 5-HT2A receptor (T102C) was noted between the accident group and control group(P> 0.05),while the genotype and allele frequency of 5-HT1B receptor (A-161T) was different in two groups(P<0.05)). (7)In accident group, the paranoid factor score of 5-HT2A receptor gene (T102C) from TC+CC genotype group was higher than that of TT genotype group(P<0.05); In control group, the paranoid factor score of 5-HT2A receptor gene (T102 C) from TC+CC genotype group was higher than that of TT genotype group(P< 0.05). (8)The results of 2×2 factorial design ANOVA showed that there was no interaction between 5-HT2A receptor gene and 5-HT1B receptor gene (F=0.86, P=0.43; F=1.10, P=0.34).Conclusion The driver’s accident proneness was related to their personality and the psychology. Among them, E, hostile and terror were risk factors for the driver’s accident proneness. The 5-HT2A receptor gene (T102C) polymorphism was associated with driver’s psychological states, but was not related to the accident proneness. The 5-HT1B receptor gene (A-161T) polymorphism was associated with accident proneness. No interaction between 5-HT2A receptor gene and 5-HT1B receptor gene has been found by comparing the driver’s psychological states. |
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