A Clinical Analysis On The Association Between Endometrial Cancer And The Components Of Metabolic Syndrome

Objective:Research the relationship between endometrial cancer and the components of metabolic syndrome, to study the influence of the components of metabolic syndrome on endometrial cancer.Methods:We collected endometrial carcinoma patients with initial diagnosis and treatment rang from January,2010 to June,2010 in the Affiliated Tumor Hospital of Guang-xi Medical University through the electronic medical record library.A total of 115 cases patients were been enrolled as study group after screening criteria; Age composition ration and menopausal status of study group as the matching conditions, we selected a total of 117 cases of benign uterine tumor patients with initial diagnosis and treatment during the corresponding period as control group.Retrospective analysis the difference of the two group of body mass index、fasting plasma glucose、2h postprandial blood glucose、systolic blood pressure、diastolic blood pressure、total cholesterol、triglycerides、high-density lipoprotein cholesterol、low-density lipoprotein cholesterol、uric acid、fibrinogen; Compare the incidence of obesity、 diabetes、hypertension、dyslipidemia、hyperuricemia、high-fibrinogen in the two group; Analysis the correlation between estrogen serum level and the metabolic components in pre/post menopause patients; The metabolic index and metabolic disease were brought into logistic regression model, to look for risk factors for endometrial cancer。Results:①The level of BMI、FPG、2h PG、TG、LDL-C、FIB in endometrial cancer patients were completely higher than those of in control group (P<0.05), the level of HDL-C in study group was obviously lower than that of in control group (P<0.05), The level of SBP. DBP. CHOL. UA have no difference in the group (P>0.05)。②The incidence of BMI>25kg/m2 for endometrial cancer patients is higher than that of in control group(44.3% VS 23.07%,P=0.001); The incidence of 2h PG≥7.8mmol/L for endometrial cancer patients (33.01%) is higher than that of in control group (11.11%); The incidence of TG>1.7mmol/L、HDL-C< 1.0mmol/L、LDL-C≥3.37mmol/L in study group were 35.65%、15.65%. 46.08%, were23.07%、8.54%、29.91% in control group, comparing the two group, endometrial cancer group were higher than control group with statistical significance(P<0.05); The incidence of FIB>4g/L were higher in sduty group than control group(40.0% VS 14.52%,P=0.000); The incidence of FPG≥6.1mmol/L、SBP≥140mmHg、DBP≥90mmHg、CHOL≥5.18mmol/L、 HUA for pre/post menopause have no difference in the group (P> 0.05)(3)The linear trend in risks were significantly increased with in the increasing number of metabolic syndrome index, compared with no metabolic abnormality, the multivariate ORs of endomatrial cancer were2.121 for one item,3.645 for two items,4.725 for three items,5.162 for four items,6.375 for more than five items.④The incidence of obesity with endomatrial cancer patients is significantly higher than control group(44.3% VS 23.07%,P=0.001), the multivariate ORs of endomatrial cancer was 2.37 for obesity, imply that risk of endometrial cancer patient with obesity is higher 2.37 times than no obesity; The incidence of diabetes with endomatrial cancer patients is significantly higher than control group (34.78% VS 1.36%, P=0.023); The incidence of dyslipidemia with endomatrial cancer patients is significantly higher than control group (71.30% VS 57.26%, P=0.026); The incidence of high-FIB (40%)is higher than control group(14.52%), its OR is 3.922; The incidence of hypertension、hyperuricemia has no obvious difference between two group。⑤The trend in risks were significantly increased with in the increasing number of metabolic disease, compared with no metabolic disease, the multivariate ORs of endomatrial cancer were 1.179 for one item,4.904 for two items,6.346 for three items,22.500for more than four items.⑥There is positive correlation between serum estrogen levels and BMI、 SBP、TG in pro-menopausal patient with endometrial cancer, the correlation coefficients are respectively 0.445、0.351、0.435, negative correlation with HDL-C (r=-0.229), there are no correlation between serum estrogen levels and FPG、2hPG、DBP、CHOL、LDL-C、UA、FIB, Postmenopausal patient with endometrial cancer with positive correlation between serum estrogen levels and BMI、TG、FIB, the correlation coefficients are respectively 0.355、0.446、0.426, however, there are no correlation with FPG、2h PG、SBP、DBP、CHOL、 HDL-C、LDL-C、UA;le factor Logistic regression analysis showed that, we can learn that BMI、FPG、2hPG、TG、LDL-C、FIB were influence factors for endomatrial cancer, the corresponding ORs were 1.131、1.396、1.214、1.508、1.266、2.196; Multivariate factor Logistic regression analysis show that BMI、2h PG、LDL-C、 FIB were main independent risk factors, with odd rations:1.087、1.130、1.130、 2.005;Conclusions:①A proportion of patients with endometrial cancer exist obvious metabolic abnormalities; ②Oesity, diabetes, dyslipidemia and high-FIB in patients endometrial cancer is more common, the risk of endometrial cancer patient with obesity or high-FIB is higher 2.37、3.922 times than no obesity or high-FIB;③The trend in risks were significantly increased with in the increasing number of metabolic syndrome index and metabolic disease;④Regardless of menopause, there is positive correlation between serum estrogen levels and BMI、TG in pro-menopausal patient with endometrial cancer;⑤The high prevalence of the abnormal components increases the risk of endometrial caner in woman patients, meanwhile, BML 2h PG、LDL-C、 FIB were main independent risk factors。It can be early distinguished people at high risk of endometrial cancer through screening metabolic abnormalities of healthy person,to achieve the goal of taking preventive and control measures and reducing the risk.