The Correlational Study On Traditional Chinese Medicine Syndrome And Napsin A, TTF-1 Expression Level In Non-small Cell Lung Cancer Tissues

Objective:To explore the relationship between TCM Syndromes and Napsin A,TTF-1 expression levels in non-small cell lung cancer tissues, for NSCLC in combination therapy to provide ideas.Method:In this study, the group of 120 patients diagnosed with NSCLC, as the case group, according to Chinese and Western double standards classify, typing, while taking 30 adjacent normal lung tissue and pulmonary benign tumors (15 cases each) as the control group. By fiberoptic bronchoscopy, percutaneous needle biopsy of metastatic lymph node biopsy sampling, using immunohistochemical SP method Napsin A, TTF-1 expression in the biopsy tissue. The obtained results were analyzed statistically.Results:1.Non-small cell lung cancer syndromes have some type of correlation (P<0.05) and histological type, which mostly adenocarcinoma deficiency toxic hot type, followed by Qi type; mostly phlegm retention in the lung squamous type; other types of non-small cell lung cancer without significant characteristics (P> 0.05).2. Non-small cell lung cancer syndromes type correlated with the clinical stage (P<0.05).3. Non-small cell lung cancer TCM syndromes and Napsin A and TTF-1 expression has some relevance. Napsin A positive expression among syndromes significant difference (P＜0.05), the syndrome to heat the main deficiency virus (38.4%), followed by Qi Deficiency (26.2%) other for phlegm retention in the lung (15.4%), pulmonary collaterals stasis syndrome (9.2%). A positive Napsin among syndromes also have significant differences (P<0.05), the syndrome to heat the main deficiency virus (37.5%), followed by Qi Deficiency (26.6%), the other for sputum wet retention in the lung (17.1%), pulmonary collaterals stasis syndrome (9.3%). Napsin A, TTF-1 negative is no correlation (P> 0.05) and TCM different syndromes.4. Non-small cell lung cancer Napsin A, TTF 1-expression has significant difference gender, smoking history (P＜0.05), whereas no significant difference in age (P> 0.05). Napsin A have the degree of lung adenocarcinoma differentiated non-small cell on a significant difference (P <0.05), in TNM stage, lymph node metastasis was no significant difference (P> 0.05),TTF-1 in differentiation, TNM stage and lymph node transfer no significant difference (P>0.05).5. Non-small cell lung cancer patient group Napsin A, next to the TTF-1 expression in normal lung tissue with the control group, the difference was statistically significant compared to benign lung (P<0.05).Conclusion:1.Napsin A difference in non-small cell lung cancer syndrome type of TTF-1 protein levels and presence of its reference index as a type of lung cancer TCM, TCM syndrome beneficial recommendations for objective standards and individualized treatment.2.Non-small cell lung cancer Napsin A and TTF-1 expression in women than in men, a history of smoking is higher than the no smoking history. There Napsin A differentiation in the degree of non-small cell lung cancer on the significant differences in the stage, lymph node metastasis was not statistically significant; TTF-1 in differentiation, stage and lymph node metastasis were not correlated.3. Napsin A and TTF-1 in lung cancer diagnosis and differential diagnosis has the important value.