Effectiveness Of Different Embryo Screening Methods Before Transplantation:A Systematic Review

Objective:To provide a theoretical basis for achieving selective single embryo transfer by systematically evaluating the effectiveness of the traditional morphological embryo screening method and other screening methods for fresh embryos or embryo vitrification after transfered. Methods:We electronically searched PubMed, EMbase, ISI Web of Knowledge, OVID-Iww-oup, Superstar Medalink, CBM, Wan-Fang Data and CNKI for studies about the effectiveness of traditional morphological embryo screening method and other screening methods from inception to July1st,2013. Two reviewers independently screened studies according to the inclusion and exclusion criteria, extracted data and evaluated the methodological quality of the included studies. Then meta-analysis was performed using the software RevMan5.1. Results:A total of4studies involving951patients were included. The results of meta-analysis showed that, for the traditional morphological embryo screening method, when compared with the NIR method and CCS method, there were no significant differences in clinical pregnancy rate (OR=0.94,95%CI0.57to1.53,P=0.80) and live birth rate (OR=0.90,95%CI0.60to1.37, P=0.63). However, significant difference was found for the embryos fragment rate (OR=0.40,95%CI0.27to0.59, P<0.00001). Conclusion:The current evidence shows that, compared with other methods, the traditional morphological embryo screening method could significantly reduce the embryos fragments rate. The results are needed to be further validate by more high-quality and large-scale studies.