The Impact Of Thalassemia On Pregnancy Outcome: A Systematic Review And Meta-analysis

Background: WHO has listed the thalassemia harm human health ofone of the six kinds of common genetic disorders. Cause serious damage tothe patient’s health. As people of prenatal care and attention of eugenic andsuperior nurture degree enhances unceasingly. But,The influence of thethalassemia pregnancy outcomes for the pregnant woman still disagree.This research according to the Cochrane system evaluation method of theanalysis of the influence of the thalassemia pregnancy outcomes for thepregnant woman. Consolidation effect by using the method of scientific andreliable.Understand the thalassemia pregnancy outcomes of pregnantwomen with normal pregnancy outcomes in pregnant women who whetherthere is a differenceAims: We aimed to whether there is a higher incidence of adversepregnancy outcomes in the pregnancy outcomes who have thalassemia.andto discuss different types of the influence of the thalassemia pregnancyoutcomes for the pregnant woman whether there is a difference, to provide basis for clinical decision making, and the future researchMethods: According to the Meta analysis and description on themethod of the Cochrane system assessment analysis discussed byresearchers and after test to determine the search term and retrievalstrategy。Studies quantifying the association between thalassemia andpregnancy outcomes were selected using the following databases: PubMed,Elsevier， Cochrane Library， isi web of knowledge Chinese JournalDatabase,、Weipu Database, Wanfang Database, and Chinese BiomedicalMedicine Database. Two researchers conducted the literature inclusion,literature quality assessment and data extraction according to the literatureinclusion and exclusion criteria. RevMan5.2were used to conduct themeta-analysis and publication bias testing.Results:13articles were included in the standard research, includingseven references in Chinese and English with six references, are cohortstudy, overall quality is better. Meta analysis found that the thalassemiapregnancy outcomes of pregnant women, compared with normal pregnancyoutcomes in pregnant women who cesarean delivery, preterm delivery andlow birth weight is a significantly increased risk,But, macrosomia in nosignificant increased risk. The cesarean delivery, preterm delivery, lowbirth weight study divided into subgroup analysis Cesarean deliverysubgroups according to the results. Alpha thalassaemia pregnant womencompared with normal pregnant women, the risk of cesarean delivery happen did not rise, beta thalassaemia pregnant women compared withnormal pregnant women. cesarean delivery occurs increased by49%。(RR=1.49，95%CI[1.28，1.72]，P＜0.05）. preterm delivery subgroupsaccording to the results. Alpha thalassaemia pregnant women comparedwith normal pregnant women, the risk of preterm delivery happen did notrise, beta thalassaemia pregnant women compared with normal pregnantwomen. preterm delivery occurs increased by111%(RR=2.11，95%CI[1.38，3.23]，P<0.05）. low birth weight subgroups according to theresults. Alpha thalassaemia pregnant women compared with normalpregnant women, the risk of preterm delivery happen did not rise, betathalassaemia pregnant women compared with normal pregnant women.preterm delivery occurs increased by73%(RR=1.73，95%CI[1.42，2.11]，P<0.05）. Funnel chart analysis literature has certain publication bias.Conclusions: Thalassaemia pregnancy outcomes in pregnant womenwho compared with normal pregnancy outcomes in pregnant women who,cesarean delivery, preterm delivery and low birth weight is significantlyincrease the risk. Macrosomia in no significant increased risk. Subgroupanalysis results show that compared with alpha thalassaemiabeta-thalassemia trait, have a higher risk of cesarean delivery preterm birthand low birth weight. sensitivity analysis results suggested that the result ofthis meta-analysis is robust.