Clinical Study Of Differentiation And Treatment Of Traditional Chinese Medicine On Optic Atrophy

Objective:To investigate the effect of TCM on optic atrophy, also named as Qingmang in Chinese traditional medical term. The vision, visual evoked potential (VEP) and Heideberg retina tomography(HRT) were measured before and after treatment.Methods:From March2007to March2014,65cases of diagnosed as Qingmang patients were enrolled in Jiangsu Hospital. Total91eyes were collected in our study. The age of patients arranged from17years to87years. According to the standard classification of syndromes,65cases of patients were divided into4groups:22cases of Ganshen group (31eyes)(Zuoguiyin),15cases of Qixue group (24eyes)(Bazhentang),16cases of Ganqi group (21eyes)(Danzhixiaoyaosan) and15cases of Qizhi group (15eyes)(Tongqiaohuoxuetang), and were administrated respectively to4groups. All patients also took methycobal500μg,3times per day. All medicines were taken for3months. Visual acuity, field of vision, VEP and HRT were obtained and compared before and after treatment.Results:The sex ratio,ages and pathogenesis were no different in4different syndromes models of Qingmang(P>0.05). Compared with before treatment, visual acuity were improved significantly (P<0.05or P<0.01) after treatment in4groups. Among22cases with31eyes in Ganshen group,10cases visual acuity were improved more than2lines,8cases were improved more than1line, with11cases did not change or even worsen. Among15cases with24eyes in Qixue group,8cases and6cases visual acuity were improved more than2lines and1line, respectively, with10cases did not change or even worsen. Among16cases with21eyes in Ganqi groups,8cases and4cases visual acuity were improved more than2lines and1line, respectively, with9cases did not change or even worsen. Among12cases of15eyes in Qizhi group,4cases and2cases visual acuity were improved more than2lines and1line, respectively, with9cases did not change or even worsen. Compared with before treatment, the average of sensitivity of vision in4groups increased significantly (P<0.05), the average missed value had decreased decline, but there were no significant differences after treatment (P>0.05). The P100VEP were significantly different (P<0.05or P<0.01). The optic cup area and rim area of HRT in4groups did not reduce significantly (P>0.05) and retinal nerve fiber layer (RNFL) was significantly thicker (P<0.05). No significant adverse reactions and side effects of4groups were observed. The improved rate in4groups had no significant difference (P>0.05). The total improved were66eyes with the improved rate of72.5%.Conclusion:TCM could treat the optic atrophy by improving vision and visual field, shorting the potential of VEP, reducing the optic never damage.